间充质软骨肉瘤是一种罕见的高恶性肿瘤，占所有软骨肉瘤的3-10%。组织病理学上，它表现为由小圆形至卵形、偶尔有旋转细胞和良性软骨小岛组成的双相人群。本研究旨在回顾性分析我们机构这类情况的临床、病理、放射学特征。这是一项回顾性描述性研究。我们的病理档案室中搜集了过去10年间所有间充质软骨肉瘤的病例。对于所有这些病例，记录了人口统计学细节，包括年龄、临床表现（骨骼/非骨骼），以及放射学特征。所有患者的治疗细节以及随访情况都从医疗记录中获取。本研究共检索到13例间充质软骨肉瘤。发病的平均年龄为33岁，男性稍微多一些。我们的3例（3/13）病例是来自非骨性软组织，其中一例在前臂，另一例在骨盆。第三例是颅内来源，表现为基于硬脑膜的顶枕部肿块，其余所有病例都是骨性来源。对于所有这些病例，进行了放射学和临床相关性研究。间充质软骨肉瘤存在多种诊断挑战，最常见的包括活检样本不足，可能导致诊断错误，尤其是小蓝圆形细胞肿瘤。更好地了解这个实体可以帮助病理学家为临床医生提供准确的诊断。

Mesenchymal chondrosarcoma is a rare high grade malignant neoplasm that accounts for 3-10% of all chondrosarcomas. Histopathologically, it shows biphasic population composed of small round to ovoid with occasional spindle cells and islands of well differentiated cartilage. The study aimed at retrospectively analysing the clinical, pathological, radiological features of these cases in our institution.This is a retrospective descriptional study. All the cases of mesenchymal chondrosarcomas were retrieved from our archives of pathology over a period of 10 years .The demographic details including the age, clinical presentation including skeletal/extraskeletal along with radiology were noted for all these cases. The treatment details along with the follow up of the patients were archived from the medical records.A total of 13 cases of mesenchymal chondrosarcoma were retrieved for our study. The mean age of presentation was 33 years with a slight male predilection. Extra skeletal soft tissue origin was noted in 3 of our cases (3/13), one case in forearm, another in pelvis. The third case was intracranial origin which presented as a dural based parieto-occipital mass and rest all had bony origin .The radiological and clinical correlation was done for all these cases.Mesenchymal chondrosarcoma presents multiple diagnostic challenges, most common include inadequate biopsy samples which may result in errors in diagnosis, namely with small blue round cell tumours .A better understanding of this entity may help the pathologists in conferring an accurate diagnosis to the clinicians.