自发现幽门螺杆菌（H. pylori）以来，已经发表了许多与H. pylori根除治疗相关的研究。本研究旨在使用定量方法评估该领域的发展。我们使用“H. pylori”和“eradication”这两个检索词结合的方式在Web of Science上搜索了1983年至2020年发表的相关文章。通过两阶段的筛选程序，纳入符合条件的研究，提取文章的标题、作者、机构、国家、研究类型、样本量、根除方案、发表年份、引用次数、期刊和H指数等数据。最终确定了1402项研究。结果显示，1994年至2003年是该领域最具影响力的时期。意大利和美国是该领域占主导地位的国家，而中国在过去十年中的发表量有了很大的增长。贝勒医学院是最具影响力的机构，Alimentary Pharmacology Therapeutics是最富生产力的期刊。H. pylori根除治疗对消化性溃疡和胃癌的影响以及根除治疗的相关研究是该领域中被最广泛引用的主题。在Maastricht/Florence IV指南发布后，四联疗法的研究超过了三联疗法。在Maastricht/Florence V指南发布后，含铋的四联疗法成为最受关注的治疗方案。本研究总结了该领域的出版物特点，确定了最具影响力的国家、机构、期刊，确定了临床H. pylori根除治疗的热门研究课题和根除方案。 (翻译者注：由于受限于中文语言表达特点，部分句子中不得不对原文进行了细微调整，但整体保持原句意思和结构。)

Numerous studies related to Helicobacter pylori (H. pylori) eradication have been published since the discovery of H. pylori. This study aimed to use a quantitative method to assess the development of this field.We performed a search of related articles from Web of Science published in 1983-2020 using a combination of the search terms "H. pylori" and "eradication". Eligible studies were included after a two-stage screening process, and the following data were extracted: title, author, institution, country, study type, sample size, eradication regimen, publication year, number of citations, journal, and H-index.A total of 1402 studies were finally identified. The results showed that the period from 1994-2003 was the most influential period in this field. Italy and the USA were dominant countries in this field, while China's publication number increased sharply in the last ten years. Baylor College of Medicine was the most influential institution. Alimentary Pharmacology Therapeutics was the most productive journal. The effects of H. pylori eradication on peptic ulcers and gastric cancer and H. pylori eradication therapy were the most cited topics in this field. After the publish of Maastricht/Florence Ⅳ guideline, the research of quadruple therapy was more than triple therapy. Bismuth-containing quadruple therapy became the most focused regimen after Maastricht/Florence Ⅴ guideline.In this study, we summarized the characteristics of the publications; identified the most influential countries, institutions, journals; identified the popular research topics and eradication regimen of clinical H. pylori eradication.© 2021 John Wiley & Sons Ltd.