这项研究旨在开发一种多功能脂质体放射增敏剂，与临床使用的6 MV X射线剂量相比，可以利用更低的辐射剂量来摧毁更多的肿瘤细胞。为了实现这一目标，首先通过EDC / NHS反应将氯光素e6（Ce6）共价结合到量子点（QDs）的外表面的功能基团上。然后，通过薄膜法制备了QDs-Ce6缀合物负载的纳米尺寸，聚乙二醇包被的以及针对肿瘤特异性的叶酸修饰的免疫脂质体分散体。研究了自由和脂质体缀合物在不同的X射线剂量（5、10、15和20 Gy）下对4T1（小鼠乳腺癌）细胞系的增殖抑制活性。结果发现，在5 Gy的X射线剂量下观察到最佳的放射增敏效应，并发现在X射线照射后，含有QDs-Ce6缀合物的免疫脂质体分散体可以比单独辐射更多地杀死26.8 ± 1.7％的癌细胞。

This study aims to develop a multifunctional liposomal radiosensitizer to destroy more tumor cells by using lower radiation doses compared to clinically used 6 MV X-ray doses. To achieve this aim, first Chlorine-e6 (Ce6) was covalently bound to functional groups of outer surfaces of quantum dots (QDs) through EDC/NHS reactions. Then, QDs-Ce6 conjugate loaded, nanosized, PEG-coated, and tumor-specific folic acid-modified immunoliposome dispersions were prepared by film method. Enhanced anti-proliferation activity of free and liposomal conjugate against 4T1 (murine breast cancer) cell lines was investigated at different X-ray doses (5, 10, 15, and 20 Gy). As a result, the best radiosensitizer effect was observed at a 5 Gy X-ray dose and it was found that following the X-ray irradiation, immunoliposome dispersions containing QDs-Ce6 conjugate killed 26.8 ± 1.7% more cancer cells than radiation alone.