脑肿瘤通常被诊断为实质性肿瘤，并是全球儿童和成人癌症相关死亡的主要原因。随着新型靶向化疗方法的不断发展，恶性胶质瘤的预后仍然不容乐观。然而，高复发率和高死亡率仍然未被解决，并与癌症干细胞（CSCs）的生物学特征密切相关。肿瘤生物学的研究已经进入新的时代，更加了解CSC的特征。CSCs作为肿瘤细胞的一个亚种，现在被视为候选治疗靶点。因此，在肿瘤的诊断和治疗中，认识CSC的生物学特性具有重要意义。本文讨论了CSC的概念及其在脑癌生长和传播中的重要作用。我们还讨论了通过特异性靶向CSCs的个性化治疗和免疫疗法来治疗脑癌的方法。©2022 Wiley Periodicals LLC。

Brain tumors are most often diagnosed with solid neoplasms and are the primary reason for cancer-related deaths in both children and adults worldwide. With recent developments in the progression of novel targeted chemotherapies, the prognosis of malignant glioma remains dismal. However, the high recurrence rate and high mortality rate remain unresolved and are closely linked to the biological features of cancer stem cells (CSCs). Research on tumor biology has reached a new age with more understanding of CSC features. CSCs, a subpopulation of whole tumor cells, are now regarded as candidate therapeutic targets. Therefore, in the diagnosis and treatment of tumors, recognizing the biological properties of CSCs is of considerable significance. Here, we have discussed the concept of CSCs and their significant role in brain cancer growth and propagation. We have also discussed personalized therapeutic development and immunotherapies for brain cancer by specifically targeting CSCs.© 2022 Wiley Periodicals LLC.