多份报告已经描述了不同癌症后患上神经胶质瘤的情况。我们根据美国监测、流行病学和终末结果（SEER）计划数据，评估了美国患者在全身恶性肿瘤后发生原发性恶性脑肿瘤的患病率。从SEER中提取了在中枢神经系统外初次患恶性肿瘤后发生原发性恶性脑肿瘤的患者的详细数据。我们使用描述性统计方法分析了患者的人口统计学和临床特征。我们还提取了按年龄、种族、性别、放疗或化疗史、组织学结果和原发癌症部位分层的标准化发病率比（SIR）。我们确定了5,212例在全身恶性肿瘤之后被诊断为原发性恶性脑肿瘤的患者。大多数患者的原发癌症是前列腺癌、乳腺癌和皮肤黑素瘤。第一次诊断癌症和随后恶性脑肿瘤之间的中位时间为53个月。胶质母细胞瘤是最常见的随后发生的恶性脑肿瘤类型。随后发生的恶性脑肿瘤诊断后的预后不良。SIR最大的差异在于种族、癌症部位和癌症类型。患有急性淋巴细胞性白血病的患者患原发性恶性脑肿瘤的风险最高。我们的研究提供了对患有原发性恶性脑肿瘤的患者进行临床数据和SIR综合分析的全面研究。遗传关系可能在随后的恶性脑肿瘤发生中起关键作用。我们的数据为未来研究探索全身恶性肿瘤和原发性恶性脑肿瘤之间潜在关联提供了方向。© 2022 The Author(s). Published by S. Karger AG, Basel.

Several reports have described glioma following different cancers. We assessed the prevalence of primary malignant brain tumors afterward systemic malignancies in patients in the USA based on Surveillance, Epidemiology, and End Results (SEER) program data.The detailed data of patients with primary malignant brain tumors following an initial malignant tumor outside the central nervous system were extracted from SEER. Descriptive statistics were used to analyze patient demographic and clinical characteristics. We also extracted standardized incidence ratios (SIRs) stratified by age, race, sex, history of radiation or chemotherapy, histology findings, and primary cancer site.We identified 5,212 patients diagnosed with primary malignant brain tumors following systemic malignancies. Most patients had prostate cancer, breast cancer, and skin melanoma as the primary cancer. The median duration between the first diagnosis of cancer and that of the subsequent malignant brain tumor was 53 months. Glioblastoma was the most common subsequent malignant brain tumor type. The prognosis after subsequent malignant brain tumor diagnosis was poor. The SIRs differed most by race, cancer site, and cancer type. Patients with acute lymphocytic leukemia had the highest risk of developing primary malignant brain tumors.Our study provides a comprehensive analysis of clinical data and the SIRs of patients with primary malignant brain tumors afterward other systemic malignancies. Genetic relationships might play a key role in subsequent malignant brain tumor origin. Our data provide directions for future studies exploring the hidden associations between systemic malignancies and primary malignant brain tumors.© 2022 The Author(s). Published by S. Karger AG, Basel.