室内接触二氧化硫（SO2）、二氧化氮（NO2）、臭氧（O3）和一氧化碳（CO）所造成的疾病负担不明确，而量化浓度-反应关系是前提条件。本文系统综述通过筛选和分析基于人群的流行病学研究的调查效应，总结了浓度-反应关系。收集了1980年至2019年发表的文献，共招募了101项研究中的19项健康结果，182项健康风险估计值。通过元分析、每次删去一项的敏感性分析和Egger's检验发现，SO2（每10μg/m3）与慢性阻塞性肺病（COPD）（合并相对风险[RRs] 1.016，95％CI：1.012-1.021）和心血管疾病（CVD）（RR 1.012，95％CI：007-1.018）分别具有强健的可靠影响。NO2（每10μg/m3）分别为1.134（1.084-1.186）、1.079（1.007-1.157）、1.055（1.010-1.101）、1.019（1.009-1.029）和1.016（1.012-1.120）的池化相对风险，分别与儿童哮喘、早产、肺癌、糖尿病和COPD有关。CO（每1mg/m3）与帕金森病（RR 1.574，95％CI：1.069-2.317）和CVD（RR 1.024，95％CI：1.011-1.038）显著相关，而O3则没有强健的影响。本研究为进一步估算四种气态污染物导致的健康负担提供了证据和依据。©2022年John Wiley＆Sons A / S。John Wiley＆Sons Ltd.出版。

The burden of disease attributed to the indoor exposure to sulfur dioxide (SO2 ), nitrogen dioxide (NO2 ), ozone (O3 ), and carbon monoxide (CO) is not clear, and the quantitative concentration-response relationship is a prerequisite. This is a systematic review to summarize the quantitative concentration-response relationships by screening and analyzing the polled effects of population-based epidemiological studies. After collecting literature published between 1980 and 2019, a total of 19 health outcomes in 101 studies with 182 health risk estimates were recruited. By meta-analysis, the leave-one-out sensitivity analysis and Egger's test for publication bias, the robust and reliable effects were found for SO2 (per 10 μg/m3 ) with chronic obstructive pulmonary diseases (COPD) (pooled relative risks [RRs] 1.016, 95% CI: 1.012-1.021) and cardiovascular diseases (CVD) (RR 1.012, 95%CI: 007-1.018), respectively. NO2 (per 10 μg/m3 ) had the pooled RRs for childhood asthma, preterm birth, lung cancer, diabetes, and COPD by 1.134 (1.084-1.186), 1.079 (1.007-1.157), 1.055 (1.010-1.101), 1.019 (1.009-1.029), and 1.016 (1.012-1.120), respectively. CO (per 1 mg/m3 ) was significantly associated with Parkinson's disease (RR 1.574, 95% CI: 1.069-2.317) and CVD (RR 1.024, 95% CI: 1.011-1.038). No robust effects were observed for O3 . This study provided evidence and basis for further estimation of the health burden attributable to the four gaseous pollutants.© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.