人类口腔包含动态和多项微生物，这些微生物独特地栖息在口腔微环境中。共生微生物群落的累积功能维持正常的稳态，但微生物群落的偏移会产生失调状态，导致局部和全身性疾病，包括龋齿、牙周炎、癌症、肥胖症和糖尿病。最近的研究报告声称存在口腔微生物失调和不同类型癌症进展之间的关联，包括口腔、胃和胰腺癌。癌症发展的不同机制，如诱导炎症反应、产生致癌物质和改变免疫系统等被提出。药物可用于治疗这些相关疾病；然而，当前的策略可能会通过不良副作用进一步恶化疾病。天然衍生的多酚分子能够显著抑制一系列全身性疾病，副作用较少。在这篇综述中，我们展示了口腔微生物的功能，并扩展了关于多酚在口腔微生物中的作用的报告，以维持健康状态和预防疾病，并着重于治疗口腔微生物相关的癌症。

The human oral cavity is comprised of dynamic and polynomial microbes which uniquely reside in the microenvironments of oral cavities. The cumulative functions of the symbiotic microbial communities maintain normal homeostasis; however, a shifted microbiota yields a dysbiosis state, which produces local and systemic diseases including dental caries, periodontitis, cancer, obesity and diabetes. Recent research reports claim that an association occurs between oral dysbiosis and the progression of different types of cancers including oral, gastric and pancreatic ones. Different mechanisms are proposed for the development of cancer, such as induction of inflammatory reactions, production of carcinogenic materials and alteration of the immune system. Medications are available to treat these associated diseases; however, the current strategies may further worsen the disease by unwanted side effects. Natural-derived polyphenol molecules significantly inhibit a wide range of systemic diseases with fewer side effects. In this review, we have displayed the functions of the oral microbes and we have extended the report regarding the role of polyphenols in oral microbiota to maintain healthy conditions and prevention of diseases with emphasis on the treatment of oral microbiota-associated cancer.