研究动态
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磁性纳米颗粒:癌症治疗的多功能工具。

Magnetic nanoparticles: multifunctional tool for cancer therapy.

发表日期:2023 Feb
作者: Sumera Khizar, Eslam Elkalla, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Abdelhamid Elaissari
来源: Expert Opinion on Drug Delivery

摘要:

癌症在全球的死亡率中居高不下。治疗癌症的传统疗法有害的副作用。考虑到这些事实,研究人员开发出新的治疗方式,带来更多的益处。在过去几年中,纳米颗粒的研发在癌症检测和治疗方面取得了重大进展。在此,介绍了使用磁性纳米颗粒(MNPs)进行化疗、免疫疗法、基因疗法、放射疗法和热疗法的癌症治疗的最新研究,以及它们的物理化学特性、优点和临床翻译的局限性也进行了讨论。MNPs 正在广泛的研究和开发,成为治疗癌症的有效模块。它们具有超顺磁性、化学、生物相容、物理和生物降解性等卓越的功能,是用于癌症治疗的非常好的工具。
Cancer has one of the highest mortality rates globally. The traditional therapies used to treat cancer have harmful adverse effects. Considering these facts, researchers have explored new therapeutic possibilities with enhanced benefits. Nanoparticle development for cancer detection, in addition to therapy, has shown substantial progress over the past few years.Herein, the latest research regarding cancer treatment employing magnetic nanoparticles (MNPs) in chemo-, immuno-, gene-, and radiotherapy along with hyperthermia is summarized, in addition to their physio-chemical features, advantages, and limitations for clinical translation have also been discussed.MNPs are being extensively investigated and developed into effective modules for cancer therapy. They are highly functional tools aimed at cancer therapy owing to their excellent superparamagnetic, chemical, biocompatible, physical, and biodegradable properties.