组蛋白乳酸化是乳酸水平和糖酵解的指标，与细胞代谢有固有联系，代表了影响细胞命运的新型表观遗传密码，包括癌变过程。通过阐明组蛋白乳酸化与肿瘤标志物的关系，我们提出组蛋白乳酸化是一种新型的表观遗传密码，预先提示细胞向恶性状态的方向发展，并倡导确定新的治疗策略或针对乳酸化的双重靶向疗法，以有效控制癌症。本综述强调了组蛋白乳酸化这一重要但鲜为人知的领域，并揭示了它的临床影响以及针对乳酸化的潜在治疗工具。

Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel epigenetic code priming cells toward the malignant state, and advocate the importance of identifying novel therapeutic strategies or dual-targeting modalities against lactylation toward effective cancer control. This review underpins important yet less-studied area in histone lactylation, and sheds insights on its clinical impact as well as possible therapeutic tools targeting lactylation.