Fas是细胞凋亡的主要受体。与对照组相比，在缺血性中风患者中报道了较高的可溶性Fas（sFas）血浓度。这项研究的目的是探讨血液sFas浓度与缺血性中风患者死亡之间是否存在关联。本研究包括入院的严重和恶性中大脑动脉梗塞（MCAI）的患者，定义为在计算机断层扫描上在此领域内超过50％的急性梗塞，格拉斯哥昏迷评分低于9分。在MMCAI诊断时确定了血清sFas水平。与幸存患者相比，非幸存性MMCAI患者（n = 27）显示出更低的血小板计数（p = 0.004），更高的血清sFas（p <0.001）和较低的GCS（p = 0.001）。多元逻辑回归发现，在控制CGS和血小板计数后，血清sFas水平与30天死亡率存在联系（OR = 1.015; 95％CI = 1.002-1.027; p = 0.02）。我们研究的主要新颖之处在于血液高sFas浓度与缺血性中风患者死亡之间存在关联。

Fas is a major receptor for cell death by apoptosis. Higher blood concentrations of soluble Fas (sFas) have been reported in patients with ischemic stroke compared to control subjects. The aim of this study was to explore the existence or not of an association between blood sFas concentrations and mortality in patients with ischemic stroke.This study included patients admitted to Intensive Care Units with severe and malignant middle cerebral artery infarction (MCAI), defined as acute infarction, in more than 50% of this territory on computed tomography and less than 9 points on the Glasgow Coma Scale (GCS). Serum sFas levels were determined at the time of diagnosis of MMCAI.Non-surviving severe MMCAI patients (n = 27) showed lower platelet count (p = 0.004), higher serum sFas (p < 0.001), and lower GCS (p = 0.001) compared to surviving patients (n = 27). Multiple logistic regression found an association of serum sFas levels and mortality at 30 days (OR = 1.015; 95% CI = 1.002-1.027; p = 0.02) after control for CGS and platelet count.The main novelty of our study was the existence of an association between high blood sFas concentrations and mortality in patients with ischemic stroke.