研究动态
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低风险乳头状甲状腺癌的经皮消融。

Percutaneous ablation of low-risk papillary thyroid cancer.

发表日期:2023 Mar 01
作者: R Michael Tuttle, Duan Li, Fourat Ridouani
来源: ENDOCRINE-RELATED CANCER

摘要:

极简主义管理选项,如积极监测和甲状腺叶切除术,越来越被认为是适用于低危乳头状甲状腺癌的正确选择患者的合理管理选项。利用针对良性甲状腺结节治疗开发的技术,超声引导经皮热消融现在正在被评估作为一个潜在的额外极简主义管理选项,适用于小的、甲状腺内的、低风险乳头状甲状腺癌。发表的回顾性数据显示,治疗了超过5000例低危乳头状甲状腺癌患者的热消融表明,通过适当的培训和正确的患者选择,这些技术可以安全有效地应用于乳头微小癌。与立即手术相比,热消融似乎具有较低的并发症发生率,且短期复发率相似。通过使用将成像特征、患者特征和医疗团队特征整合以将患者分类为理想、适当或不适当的极简主义管理选项(积极监测、甲状腺叶切除术或热消融)的临床框架,可以促进适当的患者选择。虽然回顾性的且缺乏随机前瞻性临床试验数据,但目前可获得的数据支持一个命题,即热消融技术可靠地摧毁乳头状甲状腺微小癌病变,并在经验丰富的团队在正确选择的患者中进行时,与临床可接受的肿瘤学结果相关联。
Minimalistic management options such as active surveillance and thyroid lobectomy are increasingly being accepted as reasonable management options for properly selected patients with low-risk papillary thyroid cancer. Leveraging technologies developed for the treatment of benign thyroid nodules, ultrasound-guided percutaneous thermal ablation is now being evaluated as a potential additional minimalistic management option for small, intrathyroidal, low-risk papillary thyroid cancer. Published retrospective data on more than 5000 low-risk papillary thyroid cancer patients treated with thermal ablation indicate that with appropriate training and proper patient selection, these technologies can be safely and effectively applied to papillary microcarcinomas. When compared to immediate surgery, thermal ablation appears to have lower complication rates with similar short-term rates of recurrence. Proper patient selection is facilitated by the use of a clinical framework which integrates imaging characteristics, patient characteristics, and medical team characteristics to classify a patient as ideal, appropriate, or inappropriate for minimalistic management options (active surveillance, thyroid lobectomy, or thermal ablation). While retrospective in nature and lacking randomized prospective clinical trial data, currently available data do support the proposition that thermal ablation technologies reliably destroy papillary thyroid microcarcinoma lesions and are associated with clinically acceptable oncologic outcomes when done by experienced teams in properly selected patients.