能够在自然条件下接受可见光辐照并同时释放CO和产生单线态氧的材料，对于疗法应用极为理想。此外，能够将不良副产物固定到基质中，同时不影响CO的释放和单线态氧的产生，这将使它们成为实际应用的可能。基于这些方面考虑，我们制备了两种二吡啶基取代的BODIPY‑锰(I)三羰基配合物，金属核心被系统地连接在BODIPY核心的5位和8位位置。通过电纺技术将配合物嵌入聚合物基质，形成非织造织物。结果显示，这些织物在辐照下能够释放CO并产生单线态氧。在黑暗条件下，这些杂合材料无毒，但在光照条件下对c6癌细胞具有强烈的光毒性。快速的CO释放和显著的单线态氧产生，无限的黑暗稳定性，良好的生物相容性和可忽略的黑暗毒性，使得这些织物成为光治疗应用的一个强有力的候选者。版权所有©2022 Elsevier B.V.

Materials that can simultaneously release CO and generate singlet oxygen upon visible light irradiation under ambient conditions are highly desirable for therapeutic applications. Furthermore, materials that can sequester the undesirable side products into the matrix without affecting the release of CO and singlet oxygen generation would allow them to be used for practical applications. Focussing on these aspects, we prepared two dipicolylamine appended BODIPY‑manganese(I) tricarbonyl complexes wherein the metal core was systematically tethered at 5- and 8- positions of the BODIPY core. The complexes were embedded into a polymer matrix via electrospinning and the resulting non-woven fabrics showed CO release as well as singlet oxygen generation upon irradiation. While the hybrid materials were non-toxic in dark, they were strongly photocytotoxic to c6 cancer cells when exposed to light. Rapid CO release alongside significant singlet oxygen generation, indefinite dark stability, good biocompatibility and negligible dark toxicity makes these fabrics a potent candidate for phototherapeutic applications.Copyright © 2022 Elsevier B.V. All rights reserved.