循环游离DNA (cfDNA) 是肝细胞癌的一种良好诊断工具，因为它能够全面反映肿瘤的异质性并帮助其早期检测。本研究旨在评估循环cfDNA对肝细胞癌的诊断价值。我们检索了PubMed、EMBASE、Web of Science、Cochrane Library和Scopus数据库，以识别从成立日期到2022年4月6日的所有相关文献，共找到2467篇文章。使用QUADAS-2进行方法学质量评估。筛选后，本研究纳入了15篇文章和3686名患者。纳入的文章中，合并敏感性、特异性、阳性似然比、阴性似然比、诊断比值和曲线下面积分别为0.83 (95%置信区间[CI]: 0.78, 0.87)、0.90 (95% CI: 0.86, 0.93)、8.4 (95% CI: 5.9, 12.0)、0.19 (95% CI: 0.15, 0.24)、44 (95% CI: 30, 66)和0.93 (95% CI: 0.90, 0.95)。Deek漏斗图检验没有显示显著的出版偏倚 (P = 0.28)。本荟萃分析的结果表明，循环cfDNA作为一种非侵入性检测工具，对肝细胞癌的检测具有中等灵敏度和优异的特异性 (分别为0.83和0.90)。

Circulating cell-free DNA (cfDNA) is a good diagnostic tool for hepatocellular carcinoma as it can comprehensively reflect the heterogeneity of tumors and aid in their early detection. This study aimed to assess the diagnostic value of circulating cfDNA for hepatocellular carcinoma.PubMed, EMBASE, Web of Science, Cochrane Library, and Scopus databases were searched to identify all relevant literature from their dates of establishment to 6 April 2022, and a total of 2,467 articles were found. Methodological quality assessment was performed using QUADAS-2.Fifteen articles with 3,686 patients were included in this study after screening. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve were 0.83 (95% confidence interval [CI]: 0.78, 0.87), 0.90 (95% CI: 0.86, 0.93), 8.4 (95% CI: 5.9, 12.0), 0.19 (95% CI: 0.15, 0.24), 44 (95% CI: 30, 66), and 0.93 (95% CI: 0.90, 0.95), respectively. Deek's funnel plot test did not show significant publication bias (P = 0.28).Results of this meta-analysis suggest that circulating cfDNA has moderate sensitivity and excellent specificity for the detection of hepatocellular carcinoma as a noninvasive test (0.83 and 0.90, respectively).