覆盖期：2010年至2021年 倍半萜醌/醌醇（SQs）以C15倍半萜诱导体为基础，包含C6苯醌/醌醇基团。这些物质结合了许多前所未有的碳骨架，具有不同的连接模式。SQs具有强大的抗癌、抗炎、抗微生物、抗病毒和纤溶活性，这些活性与其多样化的结构有关。代表性的avarol甚至已进入抗HIV药物的临床二期研究阶段，并且已被开发为牛皮癣的急救药物。本综述提供了2010年至2021年发现的558种新型天然SQs的概述，包括七个组和十六种结构类型子组，全面总结了它们的化学结构、谱特性、来源生物、生物活性、合成和生物合成，旨在扩大这一独特天然产品资源的应用范围。

Covering: 2010 to 2021Sesquiterpene quinone/quinols (SQs) are characterized by a C15-sesquiterpenoid unit incorporating a C6-benzoquinone/quinol moiety. Numerous unprecedented carbon skeletons have been constructed with various connection patterns between the two parts. The potent anti-cancer, anti-inflammatory, anti-microbial, anti-viral, and fibrinolytic activities of SQs are associated with their diverse structures. The representative avarol has even entered the stage of clinical phase II research as an anti-HIV agent, and was developed as paramedic medicine against psoriasis. This review provides an overall summary of 558 new natural SQs discovered between 2010 and 2021, including seven groups and sixteen structure-type subgroups, which comprehensively recapitulates their chemical structures, spectral characteristics, source organisms, biological activities, synthesis, and biosynthesis, aiming to expand the application scope of this unique natural product resource.