口腔癌（OCC）传统上与吸烟有关，但在非吸烟者中该疾病的患病率呈逐渐增加趋势。本综述研究了非吸烟者（OCCNS）中口腔癌发展的可能可调节风险因素。在2021年6月之前，通过PubMed、EMBASE、Web of Science和Scopus搜索了大量文献，并按照PRISMA指南确定了比较研究，以研究可调节的OCCNS风险因素。出版日期、人口规模和结果被索引。使用MINORS（非随机研究方法指数）评估研究质量。使用随机效应元分析框架分析了多项研究调查的因素。 文献搜索结果获得了1,625份独特的出版物。符合纳入标准的记录有52个，调查了饮酒（n = 22）、咀嚼产品（n = 18）、饮食（n = 7）、口腔卫生（n = 11）和医学共病（n = 6）。 本综述显示了研究OCCNS风险因素的大型研究的不足。需要进行进一步研究，以帮助临床医生为传统风险因素较低的患者进行风险分层。 版权所有 © 2022 Elsevier Ltd.

Oral cavity cancer (OCC) is traditionally associated with smoking, but there is an increasing prevalence of the disease among non-smokers. This review investigates possible modifiable risk factors in the development of OCC in non-smokers (OCCNS).PubMed, EMBASE, Web of Science, and Scopus were searched for publications prior to June 2021. Comparative studies investigating modifiable OCCNS risk factors were identified following PRISMA guidelines. Publication date, population size, and results were indexed. Study quality was assessed using MINORS (Methodological Index for Non-Randomized Studies). Factors examined by multiple studies were analyzed using random-effect meta-analysis framework.Literature search resulted in 1,625 unique publications. 52 records met inclusion criterion, investigating alcohol (n = 22), chewing products (n = 18), diet (n = 7), dental health (n = 11), and medical comorbidities (n = 6).This review demonstrates the paucity of large studies investigating OCCNS risk factors. Further investigation is warranted to help clinicians risk-stratify patients without traditional risk factors.Copyright © 2022 Elsevier Ltd. All rights reserved.