干扰素与骨髓增殖性肿瘤：不断发展的治疗方法。
Interferon and myeloproliferative neoplasms: Evolving therapeutic approaches.
发表日期：2023 Mar
作者：
Alok Swaroop, Diana Saleiro, Leonidas C Platanias
来源：
BIOESSAYS
摘要：
干扰素（IFNs）是细胞因子的一种多样性组合，其强大的抗肿瘤效果引起了科学家们几十年来的兴趣。在骨髓增生性肿瘤（MPN）领域，一些最持久的临床成就已经取得。在这里，我们讨论了关于IFN功能的历史和新进展，如何引领MPNs更有效的治疗方法。强调了调节新型IFN调控的ULK1通路的特别相关性和重要性，以优化IFN反应。© 2023 The Authors. BioEssays published by Wiley Periodicals LLC.
Interferons (IFNs) are a diverse group of cytokines whose potent antitumor effects have piqued the interest of scientists for decades. Some of the most sustained clinical accomplishments have been in the field of myeloproliferative neoplasms (MPNs). Here, we discuss how both historical and novel breakthroughs in our understanding of IFN function may lead to more effective therapies for MPNs. The particular relevance and importance of modulating the novel IFN-regulated ULK1 pathway to optimize IFN responses is highlighted.© 2023 The Authors. BioEssays published by Wiley Periodicals LLC.