多样化的吸烟轨迹可能会影响非手术牙周治疗和支持性牙周护理后的细胞因子表达。因此，我们旨在描述吸烟人群在牙周治疗后的细胞因子表现。我们为80名患有牙周疾病的吸烟者提供戒烟方案和非手术牙周治疗，观察了吸烟轨迹（戒烟/轻度吸烟者、中度吸烟者、重度吸烟者）。利用混合效应线性回归确定唾液白细胞介素（IL）-1β、IL-2、IL-4、IL-6、IL-8、IL-10、IL-12p70、IL-13、干扰素γ（IFN-γ）和肿瘤坏死因子-α（TNF-α）与吸烟轨迹和牙周治疗结果的关联。在戒烟/轻度吸烟者中，IL-1β与平均牙周袋深度（PPD）和平均临床附着水平（CAL）增加相关。在重度吸烟者中，IL-6与平均PPD和CAL降低相关，而在中度吸烟者中，IL-8与PPD降低相关。 TNFα与戒烟/轻度吸烟者的平均PPD和CAL降低有关，而在中度吸烟者中，TNFα与平均PPD和CAL增加相关。IL-12和IL-13与中度吸烟者的平均PPD降低有关。我们的研究结果表明，独特的吸烟暴露导致不同的细胞因子表达，进而似乎影响牙周修复。©2023作者。由Wiley Periodicals LLC代表美国牙周学会发表的《牙周病学杂志》。

Diverse smoking trajectories may influence cytokine expression after non-surgical periodontal therapy and supportive periodontal care. Thus, we aimed to describe cytokine profiles in periodontal healing after periodontal therapy in smokers.A smoking cessation program and non-surgical periodontal therapy were offered to 80 smokers with periodontitis. Smoking trajectories (quitters/light, moderate, heavy) were observed. The association of salivary interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α) with smoking trajectories and periodontal outcomes was determined using mixed-effects linear regression.Among quitters/light smokers, IL-1β was associated with an increase in mean periodontal pocket depth (PPD) and mean clinical attachment level (CAL). IL-6 was associated with a decrease in mean PPD and CAL in heavy smokers, whereas IL-8 was associated with a decrease in PPD among moderate smokers. TNFα was associated with a reduction in mean PPD and CAL among quitters/light smokers, while among moderate smokers, TNFα was associated with an increase in mean PPD and CAL. IL-12 and IL-13 were associated with a decrease in mean PPD in moderate smokers.Our findings suggest that distinctive smoking exposures induce differential cytokine expression, which, in turn, seems to influence periodontal repair.© 2023 The Authors. Journal of Periodontology published by Wiley Periodicals LLC on behalf of American Academy of Periodontology.