YTHDF1是一个经过充分研究的m6A读取蛋白，对蛋白翻译、干细胞自我更新和胚胎发育至关重要。 YTHDF1通过促进蛋白翻译或调节mRNA的稳定性等多种分子机制来调节目标基因的表达。 YTHDF1的细胞水平由复杂的转录、后转录和后翻译网络精确调节。非常坚实的证据支持YTHDF1在胚胎发育和人类癌症进展中的关键作用。 在本综述中，我们讨论了YTHDF1如何影响中枢神经、生殖和免疫系统的生理和病理生物学。因此，我们关注YTHDF1作为基因表达、复杂细胞网络、干细胞自我更新、胚胎发育和人类癌症进展中发挥的调节作用的一些相关方面。 我们提出YTHDF1是未来癌症检测、进展和预后的有前途的生物标志物。 针对YTHDF1的治疗具有潜在的治疗潜力，因为YTHDF1的过度表达与肿瘤对化疗和免疫疗法的抵抗有关。 ©2023年。作者（们）。

YTHDF1 is a well-characterized m6A reader protein that is essential for protein translation, stem cell self-renewal, and embryonic development. YTHDF1 regulates target gene expression by diverse molecular mechanisms, such as promoting protein translation or modulating the stability of mRNA. The cellular levels of YTHDF1 are precisely regulated by a complicated transcriptional, post-transcriptional, and post-translational network. Very solid evidence supports the pivotal role of YTHDF1 in embryonic development and human cancer progression. In this review, we discuss how YTHDF1 influences both the physiological and pathological biology of the central nervous, reproductive and immune systems. Therefore we focus on some relevant aspects of the regulatory role played by YTHDF1 as gene expression, complex cell networking: stem cell self-renewal, embryonic development, and human cancers progression. We propose that YTHDF1 is a promising future cancer biomarker for detection, progression, and prognosis. Targeting YTHDF1 holds therapeutic potential, as the overexpression of YTHDF1 is associated with tumor resistance to chemotherapy and immunotherapy.© 2023. The Author(s).