肌层浸润性膀胱癌（MIBC）是一种侵袭性疾病，其金标准治疗方案是联合顺铂为基础的新辅助化疗和激进的膀胱切除术（RC）。为提高患者的健康相关生命质量（HRQoL），也出现了如三联疗法（TMT）这样的膀胱保存策略。然而，了解所有这些治疗方法对HRQoL的影响对于提供个性化患者护理至关重要。不同的一般性、癌症特异性和膀胱癌特异性问卷组合可用作评价MIBC患者在治愈治疗前后的HRQoL的工具，这些问卷可在多个HRQoL领域、包括一般健康和身体、功能、社交和情感幸福感方面产生明显影响。然而，MIBC本身的诊断也可能影响HRQoL，而RC或TMT治疗后的治愈前景可能导致大多数这些领域的基线HRQoL值恢复。已经有相当数量的关于RC后HRQoL的数据可用，但关于排尿转流（回肠造口术或正位皮肤造瘘术）和手术方式（开放手术或机器人手术）对患者生活质量的影响方面报道了冲突的结果。关于TMT后HRQoL的数据很少，需要进行额外的比较研究，包括接受RC（特别是使用回肠正位皮肤造瘘术）的患者。 © 2023. Springer Nature Limited.

Muscle-invasive bladder cancer (MIBC) is an aggressive disease for which the gold-standard treatment is radical cystectomy (RC) in combination with cisplatin-based neoadjuvant chemotherapy. Bladder-sparing strategies such as trimodal therapy (TMT) have also emerged to improve health-related quality of life (HRQoL) of patients. However, an improved understanding of the effect of all these treatment modalities on HRQoL is essential to provide personalized patient care. Different combinations of generic, cancer-specific and bladder cancer-specific questionnaires can be used as instruments for HRQoL evaluation in patients with MIBC before and after curative treatments, which can largely affect multiple domains of HRQoL including general health as well as physical, functional, social and emotional well-being. However, diagnosis of MIBC per se is also likely to affect HRQoL, and the perspective of cure after RC or TMT could induce a return to baseline HRQoL values for most of these domains. A considerable amount of data on HRQoL after RC is available, but conflicting results have been reported regarding the effect of urinary diversion (ileal conduit or orthotopic neobladder) and surgical approach (open or robotic surgery) on patient quality of life. Data on HRQoL after TMT are scarce, and additional comparative studies including patients receiving RC (especially using ileal orthotopic neobladder) are needed.© 2023. Springer Nature Limited.