种族和族裔在真实世界的精准肿瘤学数据登记中的不平等现象。
Racial and ethnic disparities in a real-world precision oncology data registry.
发表日期：2023 Jan 19
作者：
Alexander T M Cheung, Elina L Palapattu, Isabella R Pompa, Christopher M Aldrighetti, Andrzej Niemierko, Henning Willers, Franklin Huang, Neha Vapiwala, Eliezer Van Allen, Sophia C Kamran
来源：
npj Precision Oncology
摘要：
生物库通过共享临床注释的基因组数据，实现了精准肿瘤学研究，但目前仍不知道这些数据登记是否反映了种族和民族少数群体中癌症真实分布情况。我们对项目基因组证据肿瘤信息交换（GENIE）进行了分析，这是一个旨在加速精准肿瘤学发现的真实世界癌症数据登记，结果表明少数族裔的代表性不足，这可能影响直接比较种族/民族间突变谱的研究的有效性，并限制了生物标志物发现的普适性。©2023. 作者。
Biorepositories enable precision oncology research by sharing clinically annotated genomic data, but it remains unknown whether these data registries reflect the true distribution of cancers in racial and ethnic minorities. Our analysis of Project Genomics Evidence Neoplasia Information Exchange (GENIE), a real-world cancer data registry designed to accelerate precision oncology discovery, indicates that minorities do not have sufficient representation, which may impact the validity of studies directly comparing mutational profiles between racial/ethnic groups and limit generalizability of biomarker discoveries to all populations.© 2023. The Author(s).