与它们在神经系统发育中的关键作用类似，神经元已经成为癌症起始、维持和进展的重要调节因子。我们重点探讨了神经系统肿瘤中，神经元和其他与正常神经功能相关的细胞类型之间的正常关系，并讨论了这些相互作用的紊乱如何促进肿瘤进化，着重于电（间隙连接）和化学（突触）耦合的建立，以及新的旁分泌关系的确立。我们还回顾了神经元-肿瘤间通讯如何造成癌症的一些并发症，包括神经病、化疗脑、癫痫和疼痛。最后，我们考虑癌症神经科学在建立肿瘤渗透风险和设计未来抗肿瘤治疗方面的意义。版权所有©2022 Elsevier公司。保留所有权利。

Similar to their pivotal roles in nervous system development, neurons have emerged as critical regulators of cancer initiation, maintenance, and progression. Focusing on nervous system tumors, we describe the normal relationships between neurons and other cell types relevant to normal nerve function, and discuss how disruptions of these interactions promote tumor evolution, focusing on electrical (gap junctions) and chemical (synaptic) coupling, as well as the establishment of new paracrine relationships. We also review how neuron-tumor communication contributes to some of the complications of cancer, including neuropathy, chemobrain, seizures, and pain. Finally, we consider the implications of cancer neuroscience in establishing risk for tumor penetrance and in the design of future anti-tumoral treatments.Copyright © 2022 Elsevier Inc. All rights reserved.