朝着精密放射治疗前进：内分泌治疗反应作为乳腺放射治疗个体化的生物标志物。
Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy.
发表日期：2023 Jan 24
作者：
S M Nashir Udden, GuemHee Baek, Kamal Pandey, Chantal Vidal, Yulun Liu, Asal S Rahimi, D Nathan Kim, Chika R Nwachukwu, Ram S Mani, Prasanna G Alluri
来源：
npj Precision Oncology
摘要：
靶向疗法，如内分泌疗法（ET）可以对癌细胞施加选择性压力，并促进适应性，从而导致治疗抗性。在这项研究中，我们展示了ET抗性在乳腺癌中通过重新编程DNA修复通路驱动放射线耐受性。我们还展示了药理学内的bromodomain和外终端域抑制可以逆转ET抗性乳腺肿瘤中的病理性DNA修复重编程，从而克服放射线治疗的抗性。 ©2023年。作者。
Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.© 2023. The Author(s).