结直肠癌（CRC）是全球第三大癌症死因。虽然在某些情况下，治疗可以增加患者的生存率并减少癌症复发，但在许多情况下，肿瘤可能会对治疗产生抵抗力，导致复发。复发和治疗抵抗的主要原因之一是癌症干细胞（CSCs）的存在。 CSC具有自我更新能力，它们的干性质会导致细胞死亡的规避，并允许新的癌细胞克隆出现。 大量的研究表明胚胎发育、生长、修复和维护组织稳态的细胞信号通路也参与了结直肠 CSCs的干性质的产生和维护。本综述讨论了Wnt、NF-κB、PI3K/AKT/mTOR、Sonic Hedgehog和Notch信号通路在结直肠CSCs中的作用，以及可能用于治疗耐药性 CRC 的调节药物。版权所有 ©2023 Elsevier B.V. 出版。

Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some cases, treatment can increase patient survival and reduce cancer recurrence, in many cases, tumors can develop resistance to therapy leading to recurrence. One of the main reasons for recurrence and therapy resistance is the presence of cancer stem cells (CSCs). CSCs possess a self-renewal ability, and their stemness properties lead to the avoidance of apoptosis, and allow a new clone of cancer cells to emerge. Numerous investigations inidicated the involvment of cellular signaling pathways in embryonic development, and growth, repair, and maintenance of tissue homeostasis, also participate in the generation and maintenance of stemness in colorectal CSCs. This review discusses the role of Wnt, NF-κB, PI3K/AKT/mTOR, Sonic hedgehog, and Notch signaling pathways in colorectal CSCs, and the possible modulating drugs that could be used in treatment for resistant CRC.Copyright © 2023. Published by Elsevier B.V.