在乳腺癌治疗中，单克隆抗体（mAbs）能够发挥多种功能角色，如靶向癌细胞，有时直接攻击它们，帮助定位和输送治疗药物到目标细胞，抑制细胞生长和阻止免疫系统抑制因子等。单克隆抗体也是重要的成功治疗策略之一，特别是对于HER2，但它们在其他类型的乳腺癌特别是三阴性乳腺癌方面尚未得到充分开发。单克隆抗体影响抗原特异性的可行性，双特异性和三特异性mAbs为更有针对性的效果打开了新的大门。与其他治疗方法相比，单克隆抗体具有多样性和功效性的使用，因此是乳腺癌治疗的合适选择。然而，mAbs治疗也会导致各种副作用，如发烧，颤抖，疲劳，头痛和肌肉疼痛，恶心/呕吐，呼吸困难，皮疹和出血。在理解这一策略的优缺点后，我们在本文中探讨了单克隆抗体诊断和治疗乳腺癌的当前和未来潜力。数据可用性：不适用。opyright © 2023 Elsevier B.V. All rights reserved.

In breast cancer, mAbs can play multifunctional roles like targeting cancer cells, sometimes directly attacking them, helping in locating and delivering therapeutic drugs to targets, inhibiting cell growth and blocking immune system inhibitors, etc. Monoclonal antibodies are also one of the important successful treatment strategies especially against HER2 but they have not been explored much for other types of breast cancers especially in triple negative breast cancers. Monoclonal antibodies impact the feasibility of antigen specificity, bispecific and trispecific mAbs have opened new doors for more targeted specific efficacy. Monoclonal antibodies can be used diversly and with efficacy as compared to other methods of treatment thus maining it a suitable candidate for breast cancer treatment. However, mAbs treatment also causes various side effects such as fever, trembling, fatigue, headache and muscle pain, nausea/vomiting, difficulty in breathing, rashes and bleeding. Understanding the pros and cons of this strategy, we have explored in this review, the current and future potential capabilities of monoclonal antibodies with respect to diagnosis and treatment of breast cancer. DATA AVAILABILITY: Not applicable.Copyright © 2023 Elsevier B.V. All rights reserved.