多份报告表明，头颈部局部晚期癌症（LAHNC）在过去的十年中有所增加。然而，由于对LAHNC的定义略有不同，所以发病趋势不易比较。为了调查荷兰口腔、咽喉、下咽和喉癌的局部晚期疾病（LAD）是否随着人口增长和老龄化而增加，我们获取了荷兰癌症登记处（NCR）的数据。研究纳入1989年至2017年口腔、咽喉、下咽和喉部原发性鳞状细胞癌的年度发病人数和欧洲标准化发病率（ESR），并按疾病程度报告。计算ESR随时间的年平均百分比变化率（APC）以评估趋势。口腔和咽喉癌的LAD的绝对数量和ESR随时间逐渐增加（在1996年之前APC:0.4，95%CI:0.1;0.8，1996年之后APC:5.7(95%CI:3.1;8.4)，分别为1.5(1.0;2.0)。下咽癌的LAD的绝对数量和ESR在1997年之前增加，而自1997年以来每年下降0.8％。喉癌病人的绝对数量随时间保持稳定，而ESR下降（APC:-0.8（95％CI:-1.1；-0.6））。荷兰LAD趋势的上升感受可以归因于口腔和咽喉癌的不断增加。下咽癌的LAD趋势呈下降趋势。虽然发病率下降，但喉癌的LAD比例占比却有所增加。版权所有©2023 Elsevier Ltd. 保留所有权利。

Several reports have indicated that locally advanced head and neck cancer (LAHNC) has increased in the past decade. However, incidence trends cannot be easily compared because slightly different definitions of LAHNC were used.To investigate if the incidence of locally advanced disease (LAD) in the oral cavity, oropharynx, hypopharynx and larynx is indeed increasing over time, considering the growing and ageing population in the Netherlands.Data were obtained from the Netherlands Cancer Registry (NCR). Primary head and neck squamous cell carcinomas of the oral cavity, oropharynx, hypopharynx and larynx diagnosed between 1989 and 2017 were included. Yearly numbers and European standardized incidence rates (ESRs) were reported by extent of disease. The annual percentage change (APC) over time in ESRs was calculated to assess trends.Absolute numbers and ESRs of LAD increased over time for oral cavity and most prominently for oropharynx carcinomas (before 1996, APC: 0.4, 95%CI: 0.1; 0.8 and APC: 5.7 (95%CI: 3.1; 8.4) after 1996: 1.5 (1.0; 2.0) respectively. For hypopharynx cancer the absolute number and ESR of LAD increased until 1997 and declined with 0.8% per year since 1997. Absolute numbers of patients with larynx cancer stayed stable over time, while ESR decreased (APC: -0.8 (95%CI: -1.1; -0.6)).The perception of an increasing trend in LAD in the Netherlands can be attributed to the increasing incidence of oral cavity and oropharynx carcinomas. For LAD of the hypopharynx a decreasing trend was observed. In larynx cancer, the proportional share of LAD of the larynx increased, even though incidence rates declined.Copyright © 2023 Elsevier Ltd. All rights reserved.