小干扰RNA（siRNA）治疗癌症是一项越来越受关注的研究重点。然而，它们在临床应用中面临的主要障碍是以期望的水平将siRNA定位输送到癌细胞。细胞膜包覆的纳米载体具有细胞膜和纳米颗粒（NPs）的两种性质的优点。在本综述中，我们重点介绍最常见的RNAi治疗和siRNA输送的细胞外和细胞内障碍。此外，我们讨论了不同细胞膜包覆的纳米载体用于靶向siRNA输送的临床应用，包括癌细胞膜（CCMs）、血小板膜、红细胞膜、干细胞膜、外泌体膜和混合膜。总之，仿生细胞膜包覆的纳米技术是癌症治疗中靶向siRNA输送的有前途的策略。 版权所有©2023 Elsevier Ltd. 保留所有权利。

Small interfering RNA (siRNA) therapeutics for cancer are a focus of increasing research interest. However, the major obstacle to their clinical application is the targeted delivery of siRNA to cancer cells at desirable levels. Cell membrane-coated nanocarriers have the advantage of combining the properties of both cell membranes and nanoparticles (NPs). In this review, we highlight the most common RNAi therapeutics and the extracellular and intracellular barriers to siRNA delivery. Moreover, we discuss clinical applications of different cell membrane-coated nanocarriers for targeted siRNA delivery, including cancer cell membranes (CCMs), platelet membranes, erythrocyte membranes, stem cell membranes, exosome membranes, and hybrid membranes. Taken together, biomimetic cell membrane-coated nanotechnology is a promising strategy for targeted siRNA delivery for cancer treatment.Copyright © 2023 Elsevier Ltd. All rights reserved.