小分子化合物靶向甲基转移酶类似物3的发展。
The development of small molecules targeting methyltransferase-like 3.
发表日期：2023 Feb 02
作者：
Hongyu Li, Qiong Zhang, Qinglan Feng, Qidong You, Xiaoke Guo
来源：
DRUG DISCOVERY TODAY
摘要：
在哺乳动物中，N6-甲基腺苷（m6A）被认为是最常见和保守的mRNA修饰。甲基转移酶类似物3（METTL3）是m6A甲基化修饰的主要调节因子。由于大量研究将METTL3失调与各种疾病和改变的生理状态，特别是癌症的生长和启动联系起来，小分子靶向METTL3可能是许多疾病治疗的有效方法。在这里，我们系统地回顾了针对METTL3靶点的小分子的发现以及它们未来的发展，以供研究该领域的研究者参考。版权所有©2023 Elsevier Ltd.
In mammals, N6-methyladenosine (m6A) is thought to be the most common and conserved mRNA modification. Methyltransferase-like 3 (METTL3) is the primary regulator of m6A methyl-transformed modification. Small molecules targeting METTL3 could be effective therapeutics for many disorders, given that a large body of research has linked METTL3 dysregulation with a variety of diseases and altered physiological states, especially with the growth and initiation of cancer. Here, we systematically reviewed the discovery of small molecules targeting METTL3, as well as their future development, for researchers studying in the field.Copyright © 2023 Elsevier Ltd. All rights reserved.