癌细胞依赖于特定的细胞外营养来维持其新陈代谢和生长。溶质载体（SLC）转运蛋白使细胞能够获取细胞外营养或在细胞器之间穿梭内部营养物质。然而，癌症中许多SLC转运蛋白的功能尚不清楚。确定促进癌症生长的关键SLC转运蛋白可能揭示重要的治疗机会。本文总结了关于SLC转运蛋白在癌症中的最新发现和知识空白。我们重点介绍用于研究这些转运蛋白的现有抑制剂、通过阻断转运蛋白治疗癌症的临床试验以及癌细胞用于逃避治疗的代偿性转运蛋白。我们提出同时针对转运蛋白或结合靶向治疗或免疫治疗作为有效癌症治疗的替代策略。©2023年。作者（们）独家授权给Springer Nature Limited。

Cancer cells rely on certain extracellular nutrients to sustain their metabolism and growth. Solute carrier (SLC) transporters enable cells to acquire extracellular nutrients or shuttle intracellular nutrients across organelles. However, the function of many SLC transporters in cancer is unknown. Determining the key SLC transporters promoting cancer growth could reveal important therapeutic opportunities. Here we summarize recent findings and knowledge gaps on SLC transporters in cancer. We highlight existing inhibitors for studying these transporters, clinical trials on treating cancer by blocking transporters, and compensatory transporters used by cancer cells to evade treatment. We propose targeting transporters simultaneously or in combination with targeted therapy or immunotherapy as alternative strategies for effective cancer therapy.© 2023. The Author(s), under exclusive licence to Springer Nature Limited.