调查显示磁场对免疫系统有不同的影响。在体液免疫反应期间，活化诱导脱氨酶（AID）和B细胞淋巴瘤-6（Bcl-6）基因表达以及白细胞介素（IL）-6和IL-21的产生是重要的。这些因素在类转换、抗体和B细胞粘合中心激活的亲和力成熟中发挥重要作用。因此，本研究调查了暴露于不同密度50赫兹MF的对这些因子的影响。80只大鼠被分为四个暴露组和对照组。治疗组暴露于1、100、500和2000微特斯拉（50赫兹，每天2小时，共60天）的磁通量密度。为了激活免疫系统，所有动物都在暴露的第31、44和58天接种了人血清白蛋白。采用逆转录-定量聚合酶链反应分析在脾脏中AID和Bcl-6基因的表达水平。酶联免疫吸附法检测了免疫前和免疫后期IL-6和IL-21的血清水平。AID在1微特斯拉磁通密度显着下降，而Bcl-6的表达没有改变。只有在500微特斯拉组的免疫后期，血清IL-6才增加。似乎暴露于1微特斯拉密度的50赫兹MF抑制AID，可能导致类转换和抗体亲和力成熟下降。另一方面，暴露于500微特斯拉可能会激活它们。这些发现证明了MF对体液免疫系统的各种潜在影响。

Investigations showed different effects of magnetic fields (MFs) on the immune system. During humoral immune responses, genes of activation-induced deaminase (AID) and B-cell lymphoma-6 (Bcl-6) are expressed and interleukin (IL)-6 and IL-21 are produced. These factors play significant roles in class switching, affinity maturation of antibodies and activations of B cells germinal centers (GCs). Therefore, this study investigated the effect of 50-Hz MFs exposure with different densities on these factors.Eighty rats were divided into four exposures and control groups. The treatment groups were exposed to magnetic flux densities of 1, 100, 500, and 2000 μT (50 Hz, 2 h/d for 60 d). To activation of the immune system, all the animals were immunized with human serum albumin on days 31, 44, and 58 of exposure. Reverse transcription-quantitative polymerase chain reaction was used to assay the expression levels of AID and Bcl-6 genes in the spleen. The serum levels of IL-6 and IL-21 were also detected by enzyme-linked immunosorbent assay at the pre-and post-immunization phases.AID expression was significantly declined at 1μT magnetic flux density, while no change was observed in the expression of Bcl-6. Serum IL-6 was increased only in the 500 μT group at the post-immunization phase.It seems exposure to 50-Hz MFs at 1 μT density, suppresses AID and may cause a decline in class switching and affinity maturation of Abs. On the other hand, exposure to 500 μT, may activate them. These findings demonstrate the various potential effects of MFs on the humoral immune system.