TREM受体的生物学。
The biology of TREM receptors.
发表日期：2023 Feb 07
作者：
Marco Colonna
来源：
NATURE REVIEWS IMMUNOLOGY
摘要：
触发在髓系细胞上表达的受体（TREMs）是一组细胞表面受体家族，主要由粒细胞、单核细胞和组织巨噬细胞表达。这些受体已被证明与炎症、神经退行性疾病、骨重塑、代谢综合征、动脉粥样硬化和癌症有关。在此，我回顾了人类和小鼠中TREM的结构、配体、信号传递模式和功能，并讨论我们仍需了解TREM生物学的挑战。©2023 Springer Nature Limited.
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.© 2023. Springer Nature Limited.