背景：关于消化道间质瘤（GIST）的内镜下切除技术的技术可行性仍然存在疑虑，主要是与肿瘤破裂和切除缘的充分性相关。本研究旨在评估新开发的无接触内镜全层切除（NT-EFTR）技术在GIST治疗中的可行性和疗效。方法：在这项回顾性研究中，包括92名接受NT-EFTR治疗的胃GIST患者。收集和分析临床病理学、内镜和随访数据。结果：中位肿瘤大小为2.5厘米，所有患者均获得了负性外科切缘的整块切除。NT-EFTR手术时间的中位数为59.5分钟。大肿瘤（> 3.0厘米）、肿瘤外生长模式和大胃缺损是手术时间延长的显著因素。患者术后在4天内出院。随访期间，所有患者均没有局部复发和远处转移。结论：NT-EFTR是胃GIST切除的可行方法，可以实现完全根治性切除。大肿瘤及其外生长和大胃缺损会影响手术难度。 Thieme。保留所有权利。

BACKGROUND : There remain concerns regarding the technical feasibility of endoscopic resection for large gastrointestinal stromal tumors (GISTs), mainly relating to the risk of tumor rupture and the adequacy of the resection margins. This study aimed to evaluate the feasibility and therapeutic outcomes of the newly developed no-touch endoscopic full-thickness resection (NT-EFTR) technique for GISTs. METHODS : In this retrospective study, 92 patients with gastric GISTs undergoing NT-EFTR were included. Clinicopathological, endoscopic, and follow-up data were collected and analyzed. RESULTS : The median tumor size was 2.5 cm and en bloc resection was achieved in all patients with negative surgical margins. The median time of the NT-EFTR procedure was 59.5 minutes. Large tumors (> 3.0 cm), extraluminal tumor growth pattern, and large gastric defects were significant contributors to long operative times. Patients were discharged within 4 days postoperatively. During follow-up, all patients were free from local recurrence and distant metastasis. CONCLUSIONS : NT-EFTR was a feasible method for the resection of gastric GISTs and can be expected to achieve complete radical resection. Large tumors with extraluminal growth and large gastric defects impact procedural difficulty.Thieme. All rights reserved.