以前的研究显示，胰腺癌（PC）的发病率在年轻女性中有所增加，但这一点尚未得到外部验证。此外，对于这一趋势的贡献因素的数据也很少。本文报告了使用不带有监测流行病学和终末统计数据（SEER）的国家癌症登记计划（NPCR）数据库对PC年龄调整发病率（aIR）进行的年龄和性别特定时间趋势分析。计算评估了PC aIR、死亡率、年平均百分比变化（APC）和平均APC（AAPC），并对其平行性和一致性进行了评估。在老年（≥55岁）和年轻（<55岁）成年人中进行了年龄特定的分析。在年轻成年人中评估了基于人口统计学、肿瘤特征和死亡率的PC发病率。在2001-2018年间，共有454,611名患者被诊断出患有PC，女性（AAPC=1.27％）和男性（AAPC=1.14％）的aIR显著增加，但没有差异（P=.37）。老年人的结果与之相似。然而，在年轻人中（53,051个病例；42.9%的女性），女性的aIR比男性更大（AAPCs=2.36%，P<.001 vs 0.62%，P=0.62），具有非平行趋势（P<.001）和AAPC的差异为1.74%（P<.001）。这个AAPC的差异似乎是由于黑人（2.23%，P<.001）、腺癌组织学亚型（0.89%，P=.003）和胰头位置（1.64%，P<.001）的aIR上升造成的。PC的死亡率在女性中没有变化，但在男性中有所下降（AAPC差异为0.54%，P=.001）。用全国范围的数据，覆盖了近64.5%的美国人口，我们在年轻女性中外部验证了PC的aIR迅速增加。在2001-2018年间，15-34岁女性和男性之间的发病率趋势有很大的差距（>200%），并且没有显示出减缓的迹象。版权所有©2023 AGA学会。Elsevier Inc.保留所有权利。

Previous studies have shown an increasing incidence of pancreatic cancer (PC), especially in younger women; however, this has not been externally validated. In addition, there are limited data about contributing factors to this trend. We report age and sex-specific time-trend analysis of PC age-adjusted incidence rates (aIR) using the National Program of Cancer Registries (NPCR) database without Surveillance Epidemiology and End Results (SEER) data.PC aIR, mortality rates, annual percentage change (APC), and average APC (AAPC) were calculated and assessed for parallelism and identicalness. Age-specific analyses were conducted in older (≥55 years) and younger (<55 years) adults. PC incidence based on demographics, tumor characteristics and mortality were evaluated in younger adults.A total of 454,611 patients were diagnosed with PC between 2001-2018 with significantly increasing aIR in women (AAPC=1.27%) and men (AAPC=1.14%) without a difference (P=.37). Similar results were seen in older adults. However, in younger adults (53,051 cases; 42.9% women), women experienced a greater increase in aIR than men (AAPCs=2.36%, P<.001 vs 0.62%, P=0.62) with non-parallel trends (P<.001) and AAPC-difference of 1.74% (P<.001). This AAPC difference appears to be due to rising aIR in Blacks (2.23%, P<.001), adenocarcinoma histopathological subtype (0.89%, P=.003), and location in the head-of-pancreas (1.64%, P<.001). PC mortality was found to be unchanged in women but declining in counterpart men (AAPC difference=0.54%, P=.001).Using nationwide data, covering ≈64.5% of US population, we externally validate a rapidly increasing aIR of PC in younger women. There was a big separation of the incidence trend between women and men aged 15-34 between 2001-2018 (>200% difference), and it did not show slowing down.Copyright © 2023 AGA Institute. Published by Elsevier Inc. All rights reserved.