胶质瘤是死亡率和患病率最高的癌症之一。复杂的生物学和获取的化学耐药性不断需要新的有效治疗方法。在王等人最近的报告中，优雅的生物信息学分析揭示了涉及G蛋白抑制性α亚单位2（Gαi2）的潜在功能和潜在的化学预防机制，该亚单位激活NF-κB，这是调节胶质瘤的主要转录因子。鉴于NF-κB在胶质瘤发展过程中参与正向调节反馈环，Gαi2是针对治疗的有吸引力的候选者。这一发现开辟了新的途径，以了解胶质形成的生物学以及发现新的有针对性的抗胶质瘤药物。©作者。

Glioma is among the cancers with the highest mortality and morbidity. The complex biology and acquired chemoresistance create a continuous need for novel, effective therapies. In a recent report by Wang et al, an elegant bioinformatic analysis revealed potential functions and underlying chemopreventive mechanisms involving G protein inhibitory α subunit 2 (Gαi2), which activates NF-κB, a master transcription factor in the regulation of glioma. Given that NF-κB takes part in positive regulatory feedback loops during glioma development, Gαi2 is an attractive candidate for targeted therapies. This discovery unlocks new avenues towards understanding the biology of gliomagenesis as well as the discovery of novel targeted antiglioma agents.© The author(s).