有越来越多的证据表明，长链非编码RNA（lncRNA）参与了胃癌（GC）的发病和进展，然而，其潜在机制仍不清楚。在本研究中，我们确定lncRNA BC002811是GC发展和进展的关键调节因子。BC002811在GC组织和细胞系中上调，并且BC002811的高表达预示着GC患者总体生存率的降低。我们的研究揭示了BC002811在体外促进了GC细胞的增殖、迁移、侵袭和抑制凋亡，并在体内加速了肿瘤生长和转移。我们还发现，BC002811上调了MMP2和MMP9，部分通过下调PTEN表达促进GC细胞转移。BC002811可以作为转录因子SOX2的分子模拟物，从而通过阻止SOX2结合到PTEN启动子，抑制PTEN的转录。我们的研究推进了BC002811在GC发病中的作用的理解，并为治疗GC转移提供了新的分子靶点。©作者们。

There is increasing evidence that long non-coding RNAs (lncRNAs) are involved in the pathogenesis and progression of gastric cancer (GC), however, the underlying mechanisms remain poorly understood. In this study, we identified lncRNA BC002811 as a critical regulator of GC development and progression. BC002811 was upregulated in GC tissues and cell lines, and that high expression of BC002811 was indicative of a reduction in overall survival of GC patients. Our research reveals that BC002811 promoted GC cell proliferation, migration, invasion, and inhibition of apoptosis in vitro, as well as accelerated tumor growth and metastasis in vivo. We also found that BC002811 upregulated MMP2 and MMP9 and promoted GC cell metastasis partially through downregulating PTEN expression. BC002811 may act as a molecular decoy for the transcription factor SOX2, thereby inhibiting the transcription of PTEN by blocking SOX2 binding to the PTEN promoter. Our study advances the understanding of the role of BC002811 in the pathogenesis of GC and provides new molecular targets for therapeutic intervention against GC metastasis.© The author(s).