尽管治疗方案包括手术、化疗和放射治疗的进步，但许多脑肿瘤的预后仍然不宜乐观，特别是当它们复发时更是如此。脑肿瘤与敏感的神经结构所处的位置经常妨碍完全的手术切除。全身治疗的毒性和长期副作用仍然令人担忧。新颖的治疗方法是必要的。NK细胞癌症治疗领域呈指数级增长，目前已成为免疫治疗创新的主要领域。这为治疗脑部恶性病变提供了新的途径。在本综述中，我们探讨了脑肿瘤微环境抑制NK细胞介导的肿瘤控制的机制，以及正在使用的创建NK细胞产品以抵制免疫抑制的方法。我们讨论了评估以NK细胞为基础的针对几种神经恶性肿瘤的临床前研究，并强调了NK细胞的分子成像技术的进展，该技术允许监测NK细胞为基础的治疗。我们回顾了当前和正在进行的神经肿瘤学领域以NK细胞为基础的临床试验。©2023年。作者(们)。

Despite advances in treatment regimens that comprise surgery, chemotherapy, and radiation, outcome of many brain tumors remains dismal, more so when they recur. The proximity of brain tumors to delicate neural structures often precludes complete surgical resection. Toxicity and long-term side effects of systemic therapy remain a concern. Novel therapies are warranted. The field of NK cell-based cancer therapy has grown exponentially and currently constitutes a major area of immunotherapy innovation. This provides a new avenue for the treatment of cancerous lesions in the brain. In this review, we explore the mechanisms by which the brain tumor microenvironment suppresses NK cell mediated tumor control, and the methods being used to create NK cell products that subvert immune suppression. We discuss the pre-clinical studies evaluating NK cell-based immunotherapies that target several neuro-malignancies and highlight advances in molecular imaging of NK cells that allow monitoring of NK cell-based therapeutics. We review current and ongoing NK cell based clinical trials in neuro-oncology.© 2023. The Author(s).