免疫变化与精神病的进展有关，但是很少有研究设计来纵向测量精神病发作期间的炎症生物标志物。我们旨在评估临床高危精神病（CHR）个体在前驱期到精神病发作期间生物标志物的变化，并将转化为精神病和非转化者与健康对照组（HC）进行比较。我们招募了394名CHR和100名HC。共有263名CHR个体完成了为期1年的随访，其中47名转化为精神病。在完成临床评估后的基线和1年后，测量了白细胞介素（IL）-1β，2，6，8，10，肿瘤坏死因子-α（TNF-α）和血管内皮生长因子水平。转化组的IL-10，IL-2和IL-6的基线血清水平显著低于非转化组（IL-10，p = 0.010；IL-2，p = 0.023；IL-6，p = 0.012）和HC（IL-6：p = 0.034）。自控比较表明，转化组的IL-2发生了显着变化（p = 0.028），而IL-6水平趋于显着（p = 0.088）。在非转化组中，TNF-α（p = 0.017）和VEGF（p = 0.037）的血清水平发生了显着变化。重复测量方差分析显示，与TNF-α（F = 4.502，p = 0.037，效应大小（η2）= 0.051）有关的时间效应，与IL-1β（F = 4.590，p = 0.036，η2 = 0.062）和IL-2（F = 7.521，p = 0.011，η2 = 0.212）有关的组效应，但无时间×组效应。发现炎症细胞因子的血清水平变化先于CHR人群的第一次精神病发作，特别是对于后来转化为精神病的个体。纵向分析支持了不同的细胞因子在后来发展为精神病和未发展为精神病的CHR个体中的不同作用。©2023 S.Karger AG，巴塞尔。

Immune alterations are associated with the progression of psychosis. However, there are few studies designed to longitudinally measure inflammatory biomarkers during psychotic episodes. We aimed to assess changes in biomarkers from the prodromal phase to psychotic episodes in individuals with clinical high risk (CHR) of psychosis and compare converters and non-converters to psychosis as well as healthy controls (HCs).We enrolled 394 individuals with CHR and 100 HCs. A total of 263 individuals with CHR completed the 1-year follow-up, and 47 had converted to psychosis. Interleukin (IL)-1β, 2, 6, 8, 10, tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor levels were measured at baseline and 1 year after completion of the clinical assessment.The baseline serum levels of IL-10, IL-2, and IL-6 were significantly lower in the conversion group than in the non-conversion group (IL-10, p = 0.010; IL-2, p = 0.023; IL-6, p = 0.012) and HC (IL-6: p = 0.034). Self-controlled comparisons showed that IL-2 changed significantly (p = 0.028), and IL-6 levels tended toward significance (p = 0.088) in the conversion group. In the non-conversion group, serum levels of TNF-α (p = 0.017) and VEGF (p = 0.037) changed significantly. Repeated measures analysis of variance revealed a significant time effect related to TNF-α (F = 4.502, p = 0.037, effect size (η2) = 0.051), a group effect related to IL-1β (F = 4.590, p = 0.036, η2 = 0.062), and IL-2 (F = 7.521, p = 0.011, η2 = 0.212), but no time × group effect.Alterations in the serum levels of inflammatory cytokines were found to precede the first episode of psychosis in the CHR population, particularly for those who later converted to psychosis. Longitudinal analysis supports the varied roles of cytokines in individuals with CHR with later psychotic conversion or non-conversion outcomes.© 2023 S. Karger AG, Basel.