HTLV-1持续性和成人T细胞白血病/淋巴瘤的肿瘤发生。
HTLV-1 persistence and the oncogenesis of adult T cell leukemia/lymphoma.
发表日期：2023 Feb 17
作者：
Charles R M Bangham
来源：
BLOOD
摘要：
人类T细胞白血病病毒1型（HTLV-1），也称人类T淋巴病毒1型，在5%的感染者中会引起被称为成人T细胞白血病/淋巴瘤（ATL）的恶性疾病，并在另外0.3%至4%之间（在流行区域变化）引起中枢神经系统的慢性进展性炎症性疾病 - HTLV-1相关脊髓病（HAM）。目前尚缺乏可靠的治疗方法，尽管近年来取得了预防和治疗ATL的有希望的进展。由于ATL通常在感染数十年后才发展，因此有必要了解病毒如何在强烈的免疫反应下在宿主体内持续存在，以及这种存在如何导致肿瘤形成。Copyright © 2023 American Society of Hematology.
Human T-cell leukemia virus type 1 (HTLV-1), also known as human T-lymphotropic virus type 1, causes the aggressive malignancy known as adult T-cell leukemia/lymphoma (ATL) in 5% of infected people, and a chronic progressive inflammatory disease of the central nervous system - HTLV-1-associated myelopathy (HAM) - in a further 0.3% to 4%, varying between endemic regions. Reliable treatments are lacking for both conditions, although there have been promising recent advances in the prevention and treatment of ATL. Since ATL typically develops after several decades of infection, it is necessary to understand how the virus persists in the host despite a strong immune response, and how this persistence results in oncogenesis.Copyright © 2023 American Society of Hematology.