以ACE2-BRD4相互作用为目标，调节DNA修复和凋亡失控来治疗结肠直肠癌。
Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis.
发表日期：2023 Feb 18
作者：
Shilan Zhang, Sabeeta Kapoor, Chakrapani Tripathi, Jorge Tovar Perez, Nivedhitha Mohan, Wan Mohaiza Dashwood, Ke Zhang, Praveen Rajendran, Roderick Dashwood
来源：
npj Precision Oncology
摘要：
ACE2在结直肠癌患者中的过表达可能增加对SARS-CoV-2感染的易感性。我们报告了在人结肠癌细胞中进行ACE2-BRD4交互作用的敲除、强制过表达和药物抑制，以介导DNA损伤/修复和凋亡方面的显著变化。对于高ACE2和高BRD4表达预测生存不良的结直肠癌患者，全BET抑制需要考虑不同BET蛋白质的促病毒/抗病毒作用在SARS-CoV-2感染期间。©2023. 作者。
ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis. In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection.© 2023. The Author(s).