磷酸二酯酶4B（PDE4B）是磷酸二酯酶（PDEs）中的关键酶，作为环腺苷酸（cAMP）的调节器。通过PDE4B/cAMP信号通路，它参与癌症过程。癌症在体内的调节是通过PDE4B发生和发展，表明PDE4B是有前途的治疗靶点。本综述涵盖了PDE4B在癌症中的功能和机制。我们总结了PDE4B可能的临床应用，并强调了开发PDE4B抑制剂的可能途径。我们还讨论了一些常见的PDEs抑制剂，并期待未来开发结合靶向PDE4B和其他PDEs药物的发展。现有的研究和临床数据可以强有力地证明PDE4B在癌症中的作用。PDE4B抑制可以有效增加细胞凋亡，抑制细胞增殖，转化，迁移等，表明PDE4B抑制可以有效抑制癌症的发展。其他PDEs可能会对抗或协调这种效果。对于PDE4B与其他PDEs在癌症中关系的进一步研究，开发多靶向PDEs抑制剂仍然是一个挑战。

Phosphodiesterase 4B (PDE4B) is a crucial enzyme in the phosphodiesterases (PDEs), acting as a regulator of cyclic adenosine monophosphate (cAMP). It is involved in cancer process through PDE4B/cAMP signaling pathway. Cancer occurs and develops with the regulation of PDE4B in the body, suggesting that PDE4B is a promising therapeutic target.This review covereed the function and mechanism of PDE4B in cancer. We summarized the possible clinical applications of PDE4B, and highlighted the possible ways to develop clinical applications of PDE4B inhibitors. We also discussed some common PDEs inhibitors, and expected the development of combined targeting PDE4B and other PDEs drugs in the future.The existing research and clinical data can strongly prove the role of PDE4B in cancer. PDE4B inhibition can effectively increase cell apoptosis, inhibit cell proliferation, transformation, migration, etc., indicating that PDE4B inhibition can effectively inhibit the development of cancer. Other PDEs may antagonize or coordinate this effect. As for the further study on the relationship between PDE4B and other PDEs in cancer, it is still a challenge to develop multi-targeted PDEs inhibitors.