胰腺癌通常导致生存率低下，治疗选择有限，因为大多数受影响的个体均表现为晚期疾病。早期检测原位胰腺肿瘤和鉴定分子治疗靶点为延长生存提供机会。尽管目前不建议对一般人群进行胰腺癌筛查，但新兴证据表明，胰腺监测可改善某些高风险人群的结果。胰腺癌流行病学的变化、胰腺监测的经验和新生物标志物的发现为胰腺癌风险评估、早期检测和预防提供了新策略的路线图。版权所有 ©2023 AGA协会。Elsevier公司出版。保留所有权利。

Pancreatic cancer usually results in poor survival with limited options for treatment, as most affected individuals present with advanced disease. Early detection of pre-invasive pancreatic neoplasia and identifying molecular therapeutic targets provide opportunities for extending survival. Although screening for pancreatic cancer is currently not recommended for the general population, emerging evidence indicate pancreatic surveillance can improve outcomes for individuals in certain high-risk groups. Changes in the epidemiology of pancreatic cancer, experience from pancreatic surveillance, and discovery of novel biomarkers provide a roadmap for new strategies for pancreatic cancer risk assessment, early detection, and prevention.Copyright © 2023 AGA Institute. Published by Elsevier Inc. All rights reserved.