体外卵母细胞成熟技术（IVM）是一项具有悠久历史，有时备受质疑的辅助生殖技术。它是一种微创技术，涉及从未或最少卵巢刺激的患者中有意采集未成熟卵母细胞并在体外培养成熟，随后进行标准程序。IVM现已被归类为非实验性，主要适用于具有高卵泡数量的患者，尤其是多囊卵巢/多囊卵巢综合症患者，以及癌症患者的生育保护。过去，IVM实践拥有许多混乱的临床方案，并且缓慢地适应新的科学见解，但最近，在动物研究中新知识的基础上，结合规定简单的患者治疗方案，已经取得了显着进展的IVM培养方法改善。这些改进导致最近IVM成为世界上越来越多的具有专业知识的中心日常实践的程度。版权所有 ©2023。Elsevier Inc.出版。

Oocyte in vitro maturation (IVM) is an assisted reproductive technology with a long and sometimes checked history. It is a minimally invasive technique involving the deliberate collection of immature oocytes from patients that have received no or minimal ovarian stimulation and the culture of oocytes to maturity in vitro, prior to standard procedures thereafter. IVM is now classified as non-experimental and is primarily indicated for patients with a high antral follicle count, especially PCO/PCOS patients, and also for fertility preservation in cancer patients. In the recent past, IVM practice has had a confusing array of clinical protocols and has been slow to adapt to new scientific insights, but recently significant advances have been made in IVM culture methods based on new knowledge from animal studies, combined with defining a simple patient treatment protocol. These improvements have led to significant recent progress in IVM practice to the extent that IVM is now routinely practiced in a growing number of centres with specialized expertise around the world.Copyright © 2023. Published by Elsevier Inc.