妊娠期糖尿病（GDM）是妊娠期最常见的代谢异常。其中，内脏脂肪组织（VAT）出现了多个异常，如肥大、炎症和脂质代谢紊乱。法呢索X受体（FXR）涉及脂肪细胞生理和炎症，因此其表达可能与肿瘤坏死因子-α（TNF-α）、白细胞介素-10（IL-10）、脂蛋白脂酶（LPL）以及两种脂肪酸转运蛋白（SLC27A2和SLC27A4）的表达有关。本研究旨在比较GDM妇女和健康妊娠（HP）妇女VAT中FXR、LPL、SLC27A2、SLC27A4、TNF-α和IL-10 mRNA的表达。其次，评估这些表达水平之间的相关性。 在50名GDM妇女和50名HP妇女中进行横断面研究。进行常规生化检测，并通过RT-qPCR测量VAT中的相对mRNA表达。 与HP妇女相比，GDM妇女的FXR和IL-10基因表达水平较低，而LPL的基因表达水平以及TNF-α / IL-10比值较高。孕前BMI是影响GDM妇女VAT中FXR水平的主要独立变量。对于所有妇女而言，LPL表达水平与SLC27A2的表达水平呈正相关。只有在GDM妇女中，IL-10的表达水平与SLC27A2和SLC27A4的表达水平呈负相关。 GDM与VAT中FXR和IL-10的表达减少、LPL的表达增加以及更高的TNF / IL-10比值相关。这些结果表明，在这种代谢紊乱中，脂质储存和促炎状态增加，表明VAT功能障碍。版权所有©2023年墨西哥社会保险研究所（IMSS）。Elsevier Inc.发表，版权所有。

Gestational diabetes mellitus (GDM) is the most frequent metabolic alteration in pregnancy. Several abnormalities in visceral adipose tissue (VAT) have been described as part of its pathophysiology including hypertrophy, inflammation and altered lipid metabolism. Farnesoid X receptor (FXR) is involved in adipocyte physiology and inflammation, so its expression may correlate with the expression of tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), lipoprotein lipase (LPL), and two fatty acid transporters (SLC27A2, and SLC27A4).To compare the FXR, LPL, SLC27A2, SLC27A4, TNF-α, and IL-10 mRNA expression in VAT between women with GDM and healthy pregnant (HP) women. Secondarily, to evaluate the potential correlation between these expression levels.Cross-sectional study of 50 GDM and 50 HP women. Conventional biochemical tests were performed and relative mRNA expression in VAT was measured by RT-qPCR.Gene expression levels of FXR and IL-10 were lower, whereas those of LPL, as well as the TNF-α/IL-10 ratio, were higher in women with GDM compared to HP. Pre-pregnancy BMI was the main significant independent variable for FXR levels in VAT from women with GDM. In all women, LPL expression levels correlated positively with those of SLC27A2. Only in women with GDM, IL-10 expression levels correlated negatively with those of SLC27A2, and SLC27A4.GDM is associated with decreased expression of FXR and IL-10 and increased expression of LPL, as well as a higher TNF/IL-10 ratio in VAT. These results suggest increased lipid storage and pro-inflammatory state indicating VAT dysfunction in this metabolic disorder.Copyright © 2023 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.