研究动态
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乳腺癌和其他激素依赖性癌症患者继续吸烟的临床影响:系统文献综述。

The clinical impact of continued smoking in patients with breast and other hormone-dependent cancer: A systematic literature review.

发表日期:2023 Feb 18
作者: Marco Del Riccio, Virginia Vettori, Sara Raimondi, Chiara Lorini, Giovanna Masala, Maria Sofia Cattaruzza, Luca Mazzarella, Guglielmo Bonaccorsi, Marianna Masiero, Benedetta Bendinelli, Giuseppe Curigliano, Gabriella Pravettoni, Elisa Pastore, Sara Gandini, Saverio Caini
来源: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

摘要:

我们进行了系统性的研究,旨在探讨在或者诊断时戒烟是否能够提高患有激素依赖性癌症(HDC)患者的生存率。我们纳入了2013-2022年共9项研究。这些研究在设计、戒烟者和持续吸烟者的定义以及除戒烟外其他预后因素的普遍发生率(例如患者的人口学特征、肿瘤特征和治疗方法)方面非常多样化。对于乳腺、卵巢和子宫内膜癌,所有纳入的研究都发现戒烟者的总体、疾病特异性和无病生存率比持续吸烟者更好。对于前列腺癌,没有证据表明戒烟与提高生存率有关。这篇文献综述提供了提示性证据,即患有乳腺、卵巢或子宫内膜癌的女性吸烟者通过戒烟可能会提高生存机会。对于这些患者,戒烟咨询应成为标准肿瘤治疗的一部分,并纳入乳腺癌筛查计划。版权所有 © 2023 Elsevier B.V.
We conducted a systematic review of studies that investigated whether quitting smoking at or around diagnosis improves survival of patients with hormone-dependent cancers (HDC). Nine studies published in 2013-2022 were included. Studies were very diverse in terms of design, definition of quitters and continued smokers, and prevalence of prognostic factors other than smoking cessation (e.g. patients' demographics, tumour characteristic, and treatments). For breast, ovarian, and endometrial cancer, all included studies found that quitters had better overall, disease specific, and disease-free survival than continued smokers. For prostate cancer, there was no evidence of an association of smoking cessation with improved survival. This literature review provided suggestive evidence that female smokers diagnosed with cancer of the breast, ovary, or endometrium may improve their chances of surviving by stopping smoking. Smoking cessation counselling should become part of standard oncological care for these patients and integrated into breast cancer screening programs.Copyright © 2023 Elsevier B.V. All rights reserved.