使用FIGO 2018宫颈癌分期系统进行腹式宫颈切除术后肿瘤学和产科结果的更新:单机构回顾性分析。
An update of oncologic and obstetric outcomes after abdominal trachelectomy using the FIGO 2018 staging system for cervical cancer: a single-institution retrospective analysis.
发表日期:2023 Jan 31
作者:
Kaoru Okugawa, Hideaki Yahata, Tatsuhiro Ohgami, Masafumi Yasunaga, Kazuo Asanoma, Hiroaki Kobayashi, Kiyoko Kato
来源:
Journal of Gynecologic Oncology
摘要:
将国际妇产科联合会(FIGO)2018年分期系统应用于我们之前研究中接受阔颈子宫切除术的所有患者,并更新肿瘤学和产科结果。我们回顾性地审查了2005年6月至2021年9月期间试图行腹式阔颈子宫切除术的患者的病历记录。所有患者均应用了FIGO 2018年宫颈癌分期系统。265名患者试图进行腹式阔颈子宫切除术。35名患者进行子宫切除手术,而230名患者成功完成了阔颈子宫切除术(转化率为13%)。应用FIGO 2018年分期系统,接受根治性阔颈子宫切除术的患者中,40%患有IA期肿瘤。在71名肿瘤直径大于等于2厘米的患者中,8名患者被分类为IA1期,14名患者被分类为IA2期。总复发率和死亡率分别为2.2%和1.3%。112名患者在阔颈子宫切除术后试图怀孕;46名患者共69次怀孕成功(怀孕率为41%)。23个妊娠在第一孕期流产,而41名婴儿在孕周23至37周之间出生;16个婴儿为足月生产(39%),25个婴儿为早产(61%)。本研究表明,未符合阔颈子宫切除术的资格和接受过度治疗的患者仍会出现,这是基于当前标准资格标准。随着FIGO 2018年分期系统的修订,阔颈子宫切除术的术前资格标准,应该改变,这些标准是基于FIGO 2009年分期系统和肿瘤大小的。© 2023年。亚洲妇科肿瘤学会、韩国妇科肿瘤学会和日本妇科肿瘤学会。
To apply the International Federation of Gynecology and Obstetrics (FIGO) 2018 staging system to all patients who underwent trachelectomy in our previous study and to update the oncologic and obstetric results.We retrospectively reviewed the medical records of patients in whom abdominal trachelectomy was attempted between June 2005 and September 2021. The FIGO 2018 staging system for cervical cancer was applied to all patients.Abdominal trachelectomy was attempted for 265 patients. Trachelectomy was converted to hysterectomy in 35 patients, and trachelectomy was completed successfully in 230 (conversion rate: 13%). Applying the FIGO 2018 staging system, 40% of the patients who underwent radical trachelectomy had stage IA tumors. Among 71 patients who had tumors measuring ≥2 cm, 8 patients were classified as stage IA1 and 14 as stage IA2. Overall recurrence and mortality rates were 2.2% and 1.3%, respectively. One hundred twelve patients attempted to conceive after trachelectomy; 69 pregnancies were achieved in 46 patients (pregnancy rate: 41%). Twenty-three pregnancies ended in first-trimester miscarriage, and 41 infants were delivered between gestational weeks 23 and 37; 16 were deliveries at term (39%) and 25 were premature deliveries (61%).This study suggested that patients judged to be ineligible for trachelectomy and patients receiving overtreatment will continue to appear using the current standard eligibility criteria. With the revisions to the FIGO 2018 staging system, the preoperative eligibility criteria for trachelectomy, which were based on the FIGO 2009 staging system and tumor size, should be changed.© 2023. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology.