PBRM1是PBAF染色质重塑复合物的一个亚单位，该亚单位在清除细胞肾细胞癌患者中发生变异的比例为40-50%。它被认为主要作为PBAF复合物的染色质结合亚单位发挥作用，但其分子机制尚不完全清楚。PBRM1含有六个串联的溴域，这些溴域已被证明在结合乙酰化的组蛋白H3赖氨酸14（H3K14ac）的核小体中起到协同作用。在这里，我们证明了PBRM1的第二个和第四个溴域也能够结合核酸，特异性地与双链RNA元素结合。破坏RNA结合口袋被发现会影响PBRM1的染色质结合并抑制PBRM1介导的细胞生长效应。©作者（们）2023年。由牛津大学出版社代表核酸研究出版。

PBRM1 is a subunit of the PBAF chromatin remodeling complex, which is mutated in 40-50% of clear cell renal cell carcinoma patients. It is thought to largely function as a chromatin binding subunit of the PBAF complex, but the molecular mechanism underlying this activity is not fully known. PBRM1 contains six tandem bromodomains which are known to cooperate in binding of nucleosomes acetylated at histone H3 lysine 14 (H3K14ac). Here, we demonstrate that the second and fourth bromodomains from PBRM1 also bind nucleic acids, selectively associating with double stranded RNA elements. Disruption of the RNA binding pocket is found to compromise PBRM1 chromatin binding and inhibit PBRM1-mediated cellular growth effects.© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.