研究动态
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测量与腹主动脉下段动脉瘤相关的存活负担。

Quantifying the Burden of Survivorship Associated with Infrarenal Abdominal Aortic Aneurysms.

发表日期:2023 Feb 20
作者: Kian Patel, Viknesh Sounderajah, Lydia Hanna, Amish Acharya, Swathikan Chidambaram, Pasha Normahani, Sheraz R Markar, Colin Bicknell
来源: JOURNAL OF VASCULAR SURGERY

摘要:

生存者拥有患有慢性病的患者和他们的照顾者的体力、心理、社交、功能和经济体验。它由9个独特的领域组成,目前尚未在非肿瘤病理学中进行深入研究,包括腹部主动脉下段动脉瘤疾病(AAA)。本综述旨在量化现有的AAA文献对生存的负担所涉及的程度。数据库:MEDLINE,EMBASE和PsychINFO在1989年至2022年9月之间搜索。随机对照试验,观察性研究和病例系列研究纳入研究。符合条件的研究必须详细说明与AAA患者的生存相关的结果。由于研究和结果之间的异质性,没有进行荟萃分析。使用特定风险偏倚工具评估研究质量。总共包括158项研究。其中,只有5个(治疗并发症、身体功能、共病、照顾者和心理健康)生存的9个领域先前已经被研究过。现有的证据质量存在不确定性,大多数研究显示中度到高风险偏倚,基于有限数量的国家,并且有着不足的跟踪期。EVAR后最常见的并发症是漏血。与OSR相比,EVAR在大多数研究中与较差的长期结果相关。在短期内,EVAR在身体功能方面表现更好,但在长期内失去了这种优势。最常见的共病是肥胖症。在照顾者方面,OSR和EVAR之间没有显着差异。抑郁症与各种共病和出院风险增加有关。本综述突出了关于AAA存活的有力证据的缺乏。因此,现代治疗指南依赖于狭窄的历史生活质量数据,并且不代表当代临床实践。因此,迫切需要重新评估与“传统”生活质量研究相关的目标和方法。版权所有©2023。Elsevier公司发表。
Survivorship encompasses the physical, psychological, social, functional, and economic experience of a living with a chronic condition for both the patient and their caregiver. It is made up of 9 distinct domains and remains understudied in non-oncological pathologies, including infrarenal abdominal aortic aneurysmal disease (AAA). This review aims to quantify the extent to which existing AAA literature addresses the burden of survivorship.The databases; MEDLINE, EMBASE and PsychINFO, were searched from 1989 through to September 2022. Randomised controlled trials, observational studies and case series studies were included. Eligible studies had to detail outcomes related to survivorship in patients with AAA. Due to heterogeneity between studies and outcomes, no meta-analysis was conducted. Study quality was assessed with specific risk of bias tools.A total of 158 studies were included. Of these, only 5 (treatment complications, physical functioning, co-morbidities, caregivers and mental health) out of 9 domains of survivorship have been previously studied. The available evidence is of variable quality; most studies display a moderate to high risk of bias, are of an observational study design, are based within a limited number of countries and consist of an insufficient follow up period. The most frequent complication following EVAR was endoleak. EVAR is associated with poorer long-term outcomes compared to OSR in most studies retrieved. EVAR showed better outcomes in regard to physical functioning in the short-term but this was lost in the long-term. The most common comorbidity studied was obesity. No significant differences were found between OSR and EVAR in terms of impact on caregivers. Depression is associated with various comorbidities and increased risk of non-hospital discharge.This review highlights the absence of robust evidence regarding survivorship in AAA. As a result, contemporary treatment guidelines are reliant upon historic quality of life data that is narrow in scope and is non-representative of contemporary clinical practice. As such, there is an urgent need to re-evaluate the aims and methodology associated with 'traditional' quality of life research moving forwards.Copyright © 2023. Published by Elsevier Inc.