脑内出血（ICH）是一种严重的脑血管疾病，具有高发病率、死亡率和残疾率。ICH的最佳治疗是一个主要的临床挑战，因为其潜在的机制仍不清楚。铁死亡，一种新型的非凋亡性编程性细胞死亡形式，是由于铁感应的脂类活性氧（ROS）的积累所导致的，从而引起细胞内氧化应激。脂类ROS会对核酸、蛋白质和细胞膜造成损害，最终导致铁死亡。在过去的十年中，铁死亡在癌症、神经退行性和其他疾病中取得了许多发现和突破。一些研究还报告称，在体内外ICH后确实会发生铁死亡，进而导致神经元死亡。然而，关于ICH后铁死亡的研究仍处于初步阶段。在本综述中，我们将总结ICH后铁死亡机制的现有证据，并回顾传统的神经元死亡方式，以确定在ICH中与铁死亡的交流，包括凋亡、坏死和自噬。此外，我们还旨在探索铁死亡在基于细胞死亡的ICH中的有前途的治疗应用。版权所有© 2023 Cao，Xiao，Liu和Zeng。

Intracerebral hemorrhage (ICH) is a serious cerebrovascular disease with high rates of morbidity, mortality, and disability. Optimal treatment of ICH is a major clinical challenge, as the underlying mechanisms remain unclear. Ferroptosis, a newly identified form of non-apoptotic programmed cell death, is characterized by the iron-induced accumulation of lipid reactive oxygen species (ROS), leading to intracellular oxidative stress. Lipid ROS causes damage to nucleic acids, proteins, and cell membranes, eventually resulting in ferroptosis. In the past 10 years, ferroptosis has resulted in plenty of discoveries and breakthroughs in cancer, neurodegeneration, and other diseases. Some studies have also reported that ferroptosis does occur after ICH in vitro and in vivo and contribute to neuronal death. However, the studies on ferroptosis following ICH are still in the preliminary stage. In this review, we will summarize the current evidence on the mechanism underlying ferroptosis after ICH. And review the traditional modes of neuronal death to identify the crosstalk with ferroptosis in ICH, including apoptosis, necroptosis, and autophagy. Additionally, we also aim to explore the promising therapeutic application of ferroptosis in cell death-based ICH.Copyright © 2023 Cao, Xiao, Liu and Zeng.