3B级滤泡区淋巴瘤的结果：由澳洲淋巴瘤联盟领导的国际研究。
Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance.
发表日期：2023 Feb 23
作者：
Allison Barraclough, James T England, Diego Villa, Joel Wight, Greg Hapgood, Jason Conn, Nicole Wong Doo, Eric Wenlong Li, Michael Gilbertson, Briony Shaw, Mark J Bishton, Malik Saeed, Sumita Ratnasingam, Chathuri Abeyakoon, Geoff Chong, Shin Hnin Wai, Matthew Ku, Hui-Peng Lee, Kathryn Fleming, Constantine Tam, Genevieve Douglas, Chan Y Cheah, Zi Yun Ng, Tukten Rolfe, Anthony K Mills, Nada Hamad, Helen Cashman, Mary Gleeson, Manjunath Narayana, Eliza A Hawkes
来源：
HAEMATOLOGICA
摘要：
G3B滤泡性淋巴瘤（FL）是一种罕见的FL亚型，存在于‘低级别’（Grade 1、2和3A FL）和弥漫性大B细胞淋巴瘤（DLBCL）之间的组织学连续性，在某些特点上似乎与两者共享。由于缺乏充分的前瞻性试验和大规模分析，其临床特征和结果尚不清楚。我们分析了来自18个国际中心的157例G3BFL病例，以及两个比较组；G3AFL （n = 302）和DLBCL （n = 548）。DLBCL或低级别FL的复合组织学在大约一半的G3BFL病例中发生。在5年的中位随访期内，G3BFL整体生存率（OS; P.
Grade (G) 3B follicular lymphoma (FL) is a rare FL subtype which exists on a histological continuum between 'low-grade' (Grade 1, 2 and 3A FL) and diffuse large B-cell lymphoma (DLBCL) appearing to share features with each. Clinical characteristics and outcomes are poorly understood due to lack of adequate representation in prospective trials and large-scale analyses. We analyzed 157 G3BFL cases from 18 international centers, and two comparator groups; G3AFL (n=302) and DLBCL (n=548). Composite histology with DLBCL or low-grade FL occurred in approximately half of G3BFL cases. With median 5 years follow-up, G3BFL overall (OS; P.