大青叶(Vitex rotundifolia L. f.)和白花大青(Vitex trifolia L.)属于大青属(Vitex)，前者演化自后者。两种植物是重要的民族药用植物，有着悠久的历史，常用于治疗头痛、发热、腹泻、脱发、伤口愈合等疾病。从传统药用、植物化学、药理活性等方面审视大青和其相关物种大青叶，为更进一步的开发和利用大青和白花大青提供参考。本文通过各种图书和在线数据库全面检索已发表的文献，以获取大青和白花大青的相关信息。在PubMed、Web of Science、中国知网(CNKI)、万方数据和百度学术中输入“(Vitex rotundifolia) OR (Vitex trifolia) OR (Fructus viticis)”等检索词，除百度学术设置时间阈值为“2018-2022”外，其它各数据库检索所有字段，结果分别为889篇、283篇、1263篇、1023篇和147篇文章。其中，排除了综述、重复、重叠数据和其他原因，最终共包括164篇文章。已鉴定出369个化合物，其中包括159个萜类、51个黄酮类、83个苯丙素类和76个其他化合物。药理学研究表明，大青叶和白花大青具有多种药理活性，如抗肿瘤、镇痛、退热、抗炎、抗氧化、抗菌和类雌激素作用。现代临床应用于治疗感冒头痛、腹泻痢疾、月经不调等疾病。作为传统药用植物，大青叶和白花大青具有丰富的化学成分和广泛的药理活性，在传统到现代的临床实践中被广泛应用。然而，对大青叶和白花大青的药理活性研究尚不深入，潜在的活性成分仍需探索。版权所有©2023 Elsevier B.V.。

Vitex rotundifolia L. f. and Vitex trifolia L. belong to the genus Vitex, and Vitex rotundifolia L. f. evolved from Vitex trifolia L. Both are essential ethnic medicinal plants with a long history, commonly used to treat headaches, fever, diarrhea, hair loss, wound recovery, and other diseases.The research status of Vitex trifolia L. and its relative species Vitex rotundifolia L. f. were reviewed from the aspects of traditional medicinal use, phytochemistry, and pharmacological activities, to provide a reference for the further development and utilization of Vitex rotundifolia L. f. and Vitex trifolia L.In this paper, a comprehensive search of published literature was conducted through various books and online databases to obtain relevant information on Vitex rotundifolia L. f. and Vitex trifolia L. The search terms "(Vitex rotundifolia) OR (Vitex trifolia) OR (Fructus viticis)" were entered in PubMed, Web of Science, China national knowledge infrastructure (CNKI), Wanfang Data, Baidu Scholar, respectively. In addition to setting the year threshold of "2018-2022" on Baidu Scholar, other databases searched all fields and found 889, 283, 1263, 1023, and 147 articles, respectively. Among them, review, repetition, overlapping data, and other reasons were excluded, and finally, a total of 164 articles were included in the review study.A total of 369 compounds have been identified, including 159 terpenoids, 51 flavonoids, 83 phenylpropanoids, and 76 other compounds. Pharmacological studies have shown that Vitex rotundifolia L. f. and Vitex trifolia L. have a variety of pharmacological activities, such as anti-tumor, analgesic, antipyretic, anti-inflammatory, antioxidant, antibacterial, and estrogen-like activity. Modern clinical use for treating cold headaches, diarrhea dysentery, irregular menstruation, and other diseases.As traditional medicinal plants, Vitex rotundifolia L. f. and Vitex trifolia L. have wealthy chemical constituents and extensive pharmacological activities and are widely used in clinical practice from traditional to modern times. However, the research on the pharmacological activities of Vitex rotundifolia L. f. and Vitex trifolia L. is not in-depth, and the potential active components still need to be explored.Copyright © 2023 Elsevier B.V. All rights reserved.