在PSC患者中进行LTx后短期和长期患病率的调查。背景数据：原发性硬化性胆管炎（PSC）是斯堪的纳维亚地区肝移植（LTx）的常见指征。最近，研究集中在长期生存率和患病率上。综合并发症指数（CCI©）通过考虑数量和严重程度精确描述手术后并发症。 比较了两组患者：经典PSC症状患者（n = 148）和增加胆管癌风险的患者（n = 51，癌前组）。计算了两个CCI©分数，一年后的和最新随访的累积总分数。此外，我们研究了可能与高CCI©有关的因素。 经典组和癌前组的1年中位数CCI©分别为29.6和26.2（P = 0.308）。总体中位数CCI©分别为43.2和46.8（P = 0.765）。1年CCI© > 42的患者的存活率显著降低。与低生存率相关的最常见并发症是胆管炎，感染和高血压。男女和不同胆道吻合术类型之间的1年和总体CCI©相似。具有pre-LTx末期肝病模型（MELD）评分> 20的患者比评分较低的患者具有更高的1年和总体CCI©（分别为36.2和52.6）。低（<22）和高（> 25 kg/m2）身体质量指数（BMI）均与1年和总体CCI©高度相关（分别为50.9和41.8），但中位数BMI与1年和总体CCI©明显降低相关（38.4，P = 0.023）。 先前确定的1年CCI©截止值为42可以显著预测LTx后的生存率。分析的PSC组之间的死亡率和患病率没有明显差异。版权所有©2023 Wolters Kluwer Health，Inc.，作者。

Investigate the short- and long-term morbidity after LTx in patients with PSC.Background Data Primary sclerosing cholangitis (PSC) is a common indication for liver transplantation (LTx) in Scandinavia. Recently, research has focused on long-term survival and morbidity. The comprehensive complication index (CCI©) precisely describes post-surgical complications, by considering both number and severity.Two patient groups were compared: those with classical PSC symptoms (n=148) and those with increased risk of cholangiocarcinoma (n=51, premalignant group). Two CCI© scores were calculated, at one year post-LTx and a cumulative overall score at the latest follow-up. Additionally, we investigated factors potentially related to high CCI©.The 1-year median CCI© were 29.6 and 26.2 in the classical and premalignant groups, respectively (P=0.308). The median overall CCI© were 43.2 and 46.8 (P=0.765), respectively. Patient survival was significantly lower in patients with 1-year CCI©>42. The most common complications associated with low survival were cholangitis, infections, and hypertension. One-year and overall CCI© were similar between sexes and different types of biliary anastomosis. Patients with pre-LTx model for end-stage liver disease (MELD) scores>20 had higher 1-year and overall CCI© (36.2 and 52.6, respectively) than those with lower MELD scores. Both low (<22) and high (>25 kg/m2) body mass indices (BMIs) were associated with high overall 1-year and overall CCI© (50.9 and 41.8, respectively), but median BMIs were associated with significantly lower 1-year and overall CCI© (38.4, P=0.023).The previously determined one-year CCI© cutoff of 42 could significantly predict survival post-LTx. Mortality and morbidity were not significantly different between the PSC groups analyzed.Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.